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Leor S. Weinberger

Researcher at Gladstone Institutes

Publications -  88
Citations -  6228

Leor S. Weinberger is an academic researcher from Gladstone Institutes. The author has contributed to research in topics: Viral replication & Viral load. The author has an hindex of 28, co-authored 81 publications receiving 5630 citations. Previous affiliations of Leor S. Weinberger include Los Alamos National Laboratory & University of California.

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Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques

Xia Jin, +13 more
- 15 Mar 1999 - 
TL;DR: It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.
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Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity

Leor S. Weinberger, +7 more
- 29 Jul 2005 - 
TL;DR: In this article, the authors present an extensive experimental/computational study of an HIV-1 model vector (LTR-GFP-IRES-Tat) and show that stochastic fluctuations in Tat influence the viral latency decision.
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Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity

Leor S. Weinberger, +7 more
- 01 Aug 2006 - 
TL;DR: Stochastic computational modeling successfully accounted for PheB and correctly predicted the dynamics of a Tat mutant that were subsequently confirmed by experiment, illustrating the importance of stochastic fluctuations in gene expression in a mammalian system.
Journal ArticleDOI

Transcriptional burst frequency and burst size are equally modulated across the human genome

Roy D. Dar, +12 more
- 23 Oct 2012 - 
TL;DR: Time-lapse fluorescence microscopy is used to analyze 8,000 individual human genomic loci and finds that at virtually all loci, episodic bursting—as opposed to constitutive expression—is the predominant mode of expression.
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Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy

Hiroshi Mohri, +13 more
- 05 Nov 2001 - 
TL;DR: Findings strongly indicate that CD4+ lymphocyte depletion seen in AIDS is primarily a consequence of increased cellular destruction, not decreased cellular production.