Jeffrey T. Safrit

TL;DR: It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.

TL;DR: It is shown that this assay reliably detects antigen-specific CTL killing of target cells, and is demonstrated that it provides a more sensitive, more informative and safer alternative to the standard 51Cr-release assay most often used to quantify CTL responses.

TL;DR: Activation of virus-specific CD4 T cells at the time of exposure to aCD4 T cell-tropic lentivirus, in the absence of an effective CD8 response, may enhance virus replication and disease.

TL;DR: The interleukin-15 superagonist N-803, combined with the depletion of CD8+ lymphocytes, induced a robust and persistent reactivation of the virus in vivo in both antiretroviral-therapy-treated SIV- Infected macaques and HIV-infected humanized mice.

TL;DR: A review of advances related to HIV cure in the last 5 years, highlighting remaining knowledge gaps and identifying priority areas for research for the next 5 years is presented in this article, where the authors discuss recent advances, knowledge gaps, and priority research areas.