J
John W. Newman
Researcher at University of California, Davis
Publications - 215
Citations - 12737
John W. Newman is an academic researcher from University of California, Davis. The author has contributed to research in topics: Epoxide hydrolase 2 & Fatty acid. The author has an hindex of 51, co-authored 208 publications receiving 11164 citations. Previous affiliations of John W. Newman include West Health & University of California, Santa Cruz.
Papers
More filters
Journal ArticleDOI
The Human Serum Metabolome
Nikolaos Psychogios,David Hau,Jun Peng,An Chi Guo,Rupasri Mandal,Souhaila Bouatra,Igor Sinelnikov,Ramanarayan Krishnamurthy,Roman Eisner,Bijaya Gautam,Nelson Young,Jianguo Xia,Craig Knox,Edison Dong,Paul Huang,Zsuzsanna Hollander,Theresa L. Pedersen,Steven R. Smith,Fiona Bamforth,Russell Greiner,Bruce M. McManus,John W. Newman,Theodore L. Goodfriend,David S. Wishart,David S. Wishart +24 more
TL;DR: This work has combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome.
Journal ArticleDOI
Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid β-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.
Sean H. Adams,Charles L. Hoppel,Kerry H. Lok,Ling Zhao,Scott W. Wong,Paul E. Minkler,Daniel H. Hwang,John W. Newman,W. Timothy Garvey +8 more
TL;DR: Results are consistent with the working hypothesis that inefficient tissue LCFA beta-oxidation, due in part to a relatively low tricarboxylic acid cycle capacity, increases tissue accumulation of acetyl-CoA and generates chain-shortened acylcarnitine molecules that activate proinflammatory pathways implicated in insulin resistance.
Journal ArticleDOI
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
Shurong Huang,Jennifer M. Rutkowsky,Ryan G. Snodgrass,Kikumi D. Ono-Moore,Dina A. Schneider,John W. Newman,John W. Newman,Sean H. Adams,Sean H. Adams,Daniel H. Hwang,Daniel H. Hwang +10 more
TL;DR: These results and additional studies with the LPS sequester polymixin B and in MyD88−/− macrophages indicated that SFA-induced activation of TLR2 or TLR4 is a fatty acid-specific effect, but not due to contaminants in BSA or fatty acid preparations.
Journal ArticleDOI
Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids
Zhigang Yu,Fengyun Xu,Linn M. Huse,Christophe Morisseau,Alison J. Draper,John W. Newman,Carol E. Parker,LeRae Graham,Marguerite M. Engler,Bruce D. Hammock,Darryl C. Zeldin,Deanna L. Kroetz +11 more
TL;DR: These studies identify sEH as a novel therapeutic target for control of blood pressure and the identification of a potent and selective inhibitor of EET hydrolysis will be invaluable in separating the vascular effects of the EET and DHET eicosanoids.
Journal ArticleDOI
Epoxide hydrolases: their roles and interactions with lipid metabolism.
TL;DR: The current state of knowledge for each epoxide hydrolase sub-type is discussed, along with a distillation of the current understanding of their endogenous roles, by reviewing the entire enzyme class together.