J
Jonathan L. Kirschman
Researcher at Georgia Institute of Technology
Publications - 15
Citations - 912
Jonathan L. Kirschman is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Interferometry & Tiltmeter. The author has an hindex of 12, co-authored 15 publications receiving 664 citations. Previous affiliations of Jonathan L. Kirschman include Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Computing in mammalian cells with nucleic acid strand exchange
Benjamin Groves,Yuan-Jyue Chen,Chiara Zurla,Sergii Pochekailov,Jonathan L. Kirschman,Philip J. Santangelo,Georg Seelig +6 more
TL;DR: This work established that functional siRNA could be activated through strand exchange, and used native mRNA as programmable scaffolds for co-localizing gates and visualizing their operation with subcellular resolution.
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A dedicated superbend x-ray microdiffraction beamline for materials, geo-, and environmental sciences at the advanced light source.
Martin Kunz,Nobumichi Tamura,Kai Chen,Alastair A. MacDowell,Richard Celestre,Matthew M. Church,Sirine C. Fakra,Edward E. Domning,James Glossinger,Jonathan L. Kirschman,Gregory Y. Morrison,D. Plate,Brian V. Smith,Tony Warwick,Valeriy V. Yashchuk,Howard A. Padmore,Ersan Üstündag +16 more
TL;DR: A new facility for microdiffraction strain measurements and microfluorescence mapping has been built at the advanced light source of the Lawrence Berkeley National Laboratory and allows a variety of experiments, which have in common the need of spatial resolution.
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High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
Cory D. Sago,Melissa P. Lokugamage,Kalina Paunovska,Daryll Vanover,Christopher M. Monaco,Nirav N. Shah,Marielena Gamboa Castro,Shannon E. Anderson,Tobi G. Rudoltz,Gwyneth N. Lando,Pooja M. Tiwari,Jonathan L. Kirschman,Nick J. Willett,Young C. Jang,Philip J. Santangelo,Anton V. Bryksin,James E. Dahlman +16 more
TL;DR: A high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional protein in vivo and identify 7C2 and 7C3, two LNPs that efficiently deliver siRNA, single-guide RNA (sgRNA), and mRNA to endothelial cells.
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Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide
Vimal Kumar Udhayakumar,Ans De Beuckelaer,Joanne McCaffrey,Cian M. McCrudden,Jonathan L. Kirschman,Daryll Vanover,Lien Van Hoecke,Kenny Roose,Kim Deswarte,Bruno G. De Geest,Stefan Lienenklaus,Philip J. Santangelo,Johan Grooten,Helen O. McCarthy,Stefaan De Koker +14 more
TL;DR: The potential of a cell‐penetrating peptide containing the amphipathic RALA motif to deliver antigen‐encoding mRNA to the immune system to elicit potent cytolytic T cell responses against the antigenic mRNA cargo is described.
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Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection.
Pooja M. Tiwari,Daryll Vanover,Kevin E. Lindsay,Swapnil Bawage,Jonathan L. Kirschman,Sushma M. Bhosle,Aaron W. Lifland,Chiara Zurla,Philip J. Santangelo +8 more
TL;DR: The data suggests that expressing membrane-anchored broadly neutralizing antibodies in the lungs could potentially be a promising pulmonary prophylaxis approach.