Julia I. Ellyard

TL;DR: It is shown that Bcl-6 positively directs Tfh cell differentiation, through combined repression of miRNAs and transcription factors.

TL;DR: BAFF may enhance humoral immunity in vivo by promoting survival of ISCs via a BCMA-dependent mechanism and have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases.

TL;DR: It is shown that CSR is triggered prior to differentiation into GC B cells or plasmablasts and is greatly diminished in GCs, and the existence of IgM-dominated GCs is demonstrated, which are unlikely to occur under the assumption of ongoing switching.

TL;DR: There is a great potential for the development of Th2-mediated immunotherapies that harness the cytotoxic activity of eosinophils, as well as many studies demonstrating the anti-tumour activity of CD4+ Th2 cells, particularly in collaboration with tumour-infiltrating granulocytes, such as eos inophils.

TL;DR: The data support a potential role for the eosinophil as an effector cell in tumor immune surveillance by determining the incidence of methylcholanthrene (MCA)-induced fibrosarcomas in IL-5 transgenic mice that have greatly enhanced levels of circulating eos inophils, CCL11 (eotaxin-1)-deficient mice that lack a key chemokine that recruits eosInophils into tissues, and the eOSinoph