Showing papers by "Julie A. Dumas published in 2021"

Baseline brain function in the preadolescents of the ABCD Study.

Abstract: The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development. This paper reports activation patterns for fMRI tasks assessing response inhibition, working memory and reward processing obtained at baseline in the longitudinal ABCD Study, providing a reference for research into adolescent brain development.

Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

Abstract: Author(s): Herting, Megan M; Uban, Kristina A; Gonzalez, Marybel Robledo; Baker, Fiona C; Kan, Eric C; Thompson, Wesley K; Granger, Douglas A; Albaugh, Matthew D; Anokhin, Andrey P; Bagot, Kara S; Banich, Marie T; Barch, Deanna M; Baskin-Sommers, Arielle; Breslin, Florence J; Casey, BJ; Chaarani, Bader; Chang, Linda; Clark, Duncan B; Cloak, Christine C; Constable, R Todd; Cottler, Linda B; Dagher, Rada K; Dapretto, Mirella; Dick, Anthony S; Dosenbach, Nico; Dowling, Gayathri J; Dumas, Julie A; Edwards, Sarah; Ernst, Thomas; Fair, Damien A; Feldstein-Ewing, Sarah W; Freedman, Edward G; Fuemmeler, Bernard F; Garavan, Hugh; Gee, Dylan G; Giedd, Jay N; Glaser, Paul EA; Goldstone, Aimee; Gray, Kevin M; Hawes, Samuel W; Heath, Andrew C; Heitzeg, Mary M; Hewitt, John K; Heyser, Charles J; Hoffman, Elizabeth A; Huber, Rebekah S; Huestis, Marilyn A; Hyde, Luke W; Infante, M Alejandra; Ivanova, Masha Y; Jacobus, Joanna; Jernigan, Terry L; Karcher, Nicole R; Laird, Angela R; LeBlanc, Kimberly H; Lisdahl, Krista; Luciana, Monica; Luna, Beatriz; Maes, Hermine H; Marshall, Andrew T; Mason, Michael J; McGlade, Erin C; Morris, Amanda S; Nagel, Bonnie J; Neigh, Gretchen N; Palmer, Clare E; Paulus, Martin P; Potter, Alexandra S; Puttler, Leon I; Rajapakse, Nishadi; Rapuano, Kristina; Reeves, Gloria; Renshaw, Perry F; Schirda, Claudiu; Sher, Kenneth J; Sheth, Chandni; Shilling, Paul D; Squeglia, Lindsay M; Sutherland, Matthew T; Tapert, Susan F; Tomko, Rachel L; Yurgelun-Todd, Deborah; Wade, Natasha E; Weiss, Susan RB; Zucker, Robert A | Abstract: AimTo examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.MethodsCross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study-a multi-site sample of 9-10 year-olds (n = 11,875)-and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels.ResultsPDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample.ConclusionsSociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Early adolescent gender diversity and mental health in the Adolescent Brain Cognitive Development study.

Abstract: BACKGROUND There are known associations between mental health symptoms and transgender identity among adults. Whether this relationship extends to early adolescents and to gender domains other than identity is unclear. This study measured dimensions of gender in a large, diverse, sample of youth, and examined associations between diverse gender experiences and mental health. METHODS The ABCD study is an ongoing, longitudinal, US cohort study. Baseline data (release 2.0) include 11,873 youth age 9/10 (48% female); and the 4,951 1-year follow-up visits (age 10/11; 48% female) completed prior to data release. A novel gender survey at the 1-year visit assessed felt-gender, gender noncontentedness, and gender nonconformity using a 5-point scale. Mental health measures included youth- and parent-reports. RESULTS Roughly half a percent of 9/10-year-olds (n = 58) responded 'yes' or 'maybe' when asked, 'Are you transgender' at baseline. Recurrent thoughts of death were more prevalent among these youth compared to the rest of the cohort (19.6% vs. 6.4%, χ2 = 16.0, p < .001). At the 1-year visit, when asked about the three dimensions of gender on a 5-point scale, 33.2% (n = 1,605) provided responses that were not exclusively and totally aligned with one gender. Significant relationships were observed between mental health symptoms and gender diversity for all dimensions assessed. CONCLUSIONS Similar to adult studies, early adolescents identifying as transgender reported increased mental health symptoms. Results also point to considerable diversity in other dimensions of gender (felt-gender, gender noncontentedness, gender nonconformity) among 10/11-year-olds, and find this diversity to be related to critical mental health symptoms. These findings add to our limited understanding of the relationship between dimensions of gender and wellness for youth.

Nicotine and Cognition in Cognitively Normal Older Adults.

Abstract: The cholinergic system has been shown to be the primary neurotransmitter system which is responsible for the cognitive symptoms associated with dementia; its role in healthy non-demented older adults remains a gap in the literature. Understanding the effects of age-related functional changes on the nicotinic system will address this knowledge gap. As the older adult population grows and hence the importance of understanding cognitive changes that impact functional abilities and everyday life. In this article we examine the benefits of using nicotine as a method for improving cognition in non-demented healthy older adults which may have the potential for slowing neurodegeneration in aging. Furthermore, we discuss how nicotine can play a crucial role in maintaining cognitive abilities throughout normal cognitive aging.

Lifetime stress exposure, cognition, and psychiatric wellbeing in women.

Abstract: Objectives:Although life stress has been associated with worse cognitive and psychiatric functioning, few studies on this topic have examined these associations in older adults and no studies to date have assessed lifetime stress exposure in this context.Method:To address this important issue, we investigated associations between lifetime stress exposure, cognition, and psychiatric wellbeing in 44 women aged 60 and older who completed a comprehensive lifetime stress exposure inventory, two memory tasks, and a complete psychiatric assessment.Results:As hypothesized, greater acute and chronic lifetime stress exposure were both related to poorer psychiatric functioning and more somatic health complaints. Greater lifetime stress exposure was also associated with poorer subjective cognition as indicated by memory and thought problems but not objective indices of memory function.Conclusion:Screening for high life stress exposure may therefore help identify older women at increased risk of experiencing negative psychiatric and cognitive outcomes.

The generalizability of empirically derived syndromes of collateral-reported elder psychopathology across 11 societies.

Abstract: The purpose of this study was to test whether a syndrome model of elder psychopathology derived from collateral ratings, such as from spouses and adult children, in the United States would be generalizable in 11 other societies. Societies represented South America, Asia, and Europe. The Older Adult Behavior Checklist (OABCL) was completed by collateral informants for 6141 60- to 102-year-olds. The tested model comprised syndromes designated as Anxious/Depressed, Worries, Somatic Complaints, Functional Impairment, Memory/Cognition Problems, Thought Problems, and Irritable/Disinhibited. The model was tested using confirmatory factor analyses in each society separately. The primary model fit index showed a good fit for all societies, while the secondary model fit indices showed acceptable to a good fit for all societies. The items loaded strongly on their respective factors, with a median item loading of 0.69 across the 11 societies. By syndrome, the overall median item loadings ranged from 0.47 for Worries to 0.77 for Functional Impairment. The OABCL syndrome structure was thus generalizable across the tested societies. The OABCL can be used for broad assessment of psychopathology for elders of diverse backgrounds in nursing services and research.