J
Julie Helft
Researcher at Curie Institute
Publications - 42
Citations - 9580
Julie Helft is an academic researcher from Curie Institute. The author has contributed to research in topics: CD8 & T cell. The author has an hindex of 23, co-authored 38 publications receiving 8264 citations. Previous affiliations of Julie Helft include Icahn School of Medicine at Mount Sinai & University of Paris.
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Journal ArticleDOI
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
TL;DR: This review discusses major advances in the understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
Journal ArticleDOI
Origin of the lamina propria dendritic cell network.
Milena Bogunovic,Florent Ginhoux,Julie Helft,Limin Shang,Daigo Hashimoto,Melanie Greter,Kang Liu,Claudia Jakubzick,Molly A. Ingersoll,Marylene Leboeuf,E. Richard Stanley,Michel C. Nussenzweig,Sergio A. Lira,Gwendalyn J. Randolph,Miriam Merad +14 more
TL;DR: It is shown that monocytes gave rise exclusively to CD103(-)CX(3)CR1(+) lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands.
Journal ArticleDOI
The origin and development of nonlymphoid tissue CD103+ DCs
Florent Ginhoux,Kang Liu,Julie Helft,Milena Bogunovic,Melanie Greter,Daigo Hashimoto,Jeremy Price,Na Yin,Jonathan S. Bromberg,Sergio A. Lira,E. Richard Stanley,Michel C. Nussenzweig,Miriam Merad +12 more
TL;DR: It is shown that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria.
Journal ArticleDOI
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
Julie Helft,Jan P. Böttcher,Probir Chakravarty,Santiago Zelenay,Jatta Huotari,Barbara U. Schraml,Delphine Goubau,Caetano Reis e Sousa +7 more
TL;DR: It is demonstrated that CD11c(+)MHCII(+) BMDCs are in fact a heterogeneous group of cells that comprises conventional DCs and monocyte-derived macrophages, and have important implications for the interpretation of a vast array of data obtained with DC culture systems.