K
K. N. Houk
Researcher at University of California, Los Angeles
Publications - 544
Citations - 19761
K. N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 68, co-authored 478 publications receiving 17032 citations. Previous affiliations of K. N. Houk include University of Pittsburgh & Leibniz University of Hanover.
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Mechanism and stereoselectivity of the stepwise 1,3-dipolar cycloadditions between a thiocarbonyl ylide and electron-deficient dipolarophiles: a computational investigation.
Yu Lan,K. N. Houk +1 more
TL;DR: The 1,3-dipolar cycloadditions of a thiocarbonyl ylide to dimethyl 2, 3-dicyanofumarate and 2,3, dicyanomaleate have been studied with DFT computations and the low stereoselectivity was found to arise from rotations about single bonds in the intermediates that compete with cyclization.
Journal ArticleDOI
A Biocatalytic Platform for Synthesis of Chiral α- Trifluoromethylated Organoborons
Xiongyi Huang,Marc Garcia-Borràs,Kun Miao,S. B. Jennifer Kan,Arjun Zutshi,K. N. Houk,Frances H. Arnold +6 more
TL;DR: An enzymatic platform for highly enantioselective carbene B–H bond insertion to yield versatile α-trifluoromethylated (α-CF3) organoborons, an important class of organofluorine molecules that contain stereogenic centers bearing both CF3 and boron groups.
Journal ArticleDOI
Theory of Substituent Effects on Pericyclic Reaction Rates: Alkoxy Substituents in the Claisen Rearrangement
Hi Young Yoo,K. N. Houk +1 more
TL;DR: In this article, transition structures, activation energies, and reaction energies were calculated by ab initio quantum mechanical methods for the Claisen rearrangements of five hydroxy-substituted allyl vinyl ethers.