K
K. N. Houk
Researcher at University of California, Los Angeles
Publications - 544
Citations - 19761
K. N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 68, co-authored 478 publications receiving 17032 citations. Previous affiliations of K. N. Houk include University of Pittsburgh & Leibniz University of Hanover.
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Computational Design of Enhanced Enantioselectivity in Chiral Phosphoric Acid-Catalyzed Oxidative Desymmetrization of 1,3-Diol Acetals.
TL;DR: DFT calculations demonstrate that the acetal protecting group is highly influential for high enantioselectivity, and a simple but effective new protecting group has been designed for desymmetrization of 1,3-diols.
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A theoretical study of intramolecular Diels-Alder and 1,3-dipolar cycloaddition stereoselectivity using ab initio methods, semiempirical methods, and a tandem quantum mechanic-molecular mechanic method
TL;DR: In this article, the parent Diels-Alder reactions forming 6-5 and 6-6 systems are rationalized for three methylene groups (formation of a five-membered ring), and the strain in the transition structure (TS) causes the addends to twist about the forming bonds.
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Energies and properties of ions involved in electrophilic halogenations: singlet and triplet states of halogen cations (X+, X3+, and X42+) and hydrohalonium ions (HX2+ and H2X+)
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Substituent Effects on Torquoselectivity. Computational Investigations of the Thermal Ring Openings of Cyclobutenes Fused to Substituted Cyclohexenes
Kensuke Nakamura,K. N. Houk +1 more
Journal ArticleDOI
Iterative Catalysis in the Biosynthesis of Mitochondrial Complex II Inhibitors Harzianopyridone and Atpenin B
Undramaa Bat-Erdene,Daiki Kanayama,Dan Tan,William C. Turner,K. N. Houk,Masao Ohashi,Yi Tang +6 more
TL;DR: The penta-substituted pyridine natural products harzianopyridone and atpenins are potent inhibitors of mitochondrial complex II and the pathways of these compounds from their fungal pro-ducers are identified, and the biosynthetic steps require multiple itera-tive enzymes.