K
K. N. Houk
Researcher at University of California, Los Angeles
Publications - 544
Citations - 19761
K. N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 68, co-authored 478 publications receiving 17032 citations. Previous affiliations of K. N. Houk include University of Pittsburgh & Leibniz University of Hanover.
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Electrocyclic ring openings of dialkylcyclobutenes: anomalies explained
TL;DR: In this article, the electrocyclic reactions of dialkylcyclobutenes were examined with use of ab initio molecular orbital theory, and it was shown that the product distribution can be explained as a result of more favorable gauche interactions upon inward rotation of the larger ethyl group.
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Overriding Traditional Electronic Effects in Biocatalytic Baeyer− Villiger Reactions by Directed Evolution
Guangyue Li,Guangyue Li,Marc Garcia-Borràs,Maximilian J. L. J. Fürst,Adriana Ilie,Adriana Ilie,Marco W. Fraaije,K. N. Houk,Manfred T. Reetz,Manfred T. Reetz +9 more
TL;DR: It was found that the mutations introduced by directed evolution induce crucial changes in the conformation of the respective Criegee intermediates and transition states in the binding pocket of the enzyme to aid future protein engineering of BVMOs.
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Bioorthogonal release of sulfonamides and mutually orthogonal liberation of two drugs.
Zhuzhou Shao,Wei Liu,Huimin Tao,Fang Liu,Ruxin Zeng,Pier Alexandre Champagne,Yang Cao,K. N. Houk,Yong Liang +8 more
TL;DR: The mutual orthogonality between the sydnonimine-DIBAC and benzonorbornadiene-tetrazine cycloaddition pairs is discovered, which can be used for selective and simultaneous liberation of sulfonamide and primary amine drugs.
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Noncovalent Interactions of a Benzo[a]pyrene Diol Epoxide with DNA Base Pairs: Insight into the Formation of Adducts of (+)-BaP DE-2 with DNA
TL;DR: Noncovalent complexes of a tumorigenic benzo[a]pyrene diol epoxide with the guanine-cytosine and adenine-thymine base pairs have been examined computationally and predicted five thermodynamically accessible complexes of AT with (+)-BaP DE-2 that are compatible with intact DNA.
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Experimental Determination of the Activation Parameters and Stereoselectivities of the Intramolecular Diels−Alder Reactions of 1,3,8-Nonatriene, 1,3,9-Decatriene, and 1,3,10-Undecatriene and Transition State Modeling with the Monte Carlo-Jumping Between Wells/Molecular Dynamics Method
Matthias K. Diedrich,Frank-Gerrit Klärner, ,†,Brett R. Beno,K. N. Houk,and Hanoch Senderowitz,W. Clark Still +5 more
TL;DR: In this paper, the Monte Carlo-Jumping between Wells/Stochastic Dynamics [MC(JBW)/SD] method was used as a means to predict stereoselectivities.