K
K. N. Houk
Researcher at University of California, Los Angeles
Publications - 544
Citations - 19761
K. N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 68, co-authored 478 publications receiving 17032 citations. Previous affiliations of K. N. Houk include University of Pittsburgh & Leibniz University of Hanover.
Papers
More filters
Journal ArticleDOI
Biosynthesis of thiocarboxylic acid-containing natural products
Liao-Bin Dong,Jeffrey D. Rudolf,Dingding Kang,Nan Wang,Cyndi Qixin He,Youchao Deng,Yong Huang,K. N. Houk,Yanwen Duan,Ben Shen +9 more
TL;DR: The authors identify a thioacid cassette encoding two proteins, PtmA3 and PtmU4, responsible for carboxylate activation by coenzyme A and sulfur transfer, respectively, which suggest that thiocarboxylic acid, as an alternative pharmacophore, and thioPTM and ThioPTN may be considered for future drug discovery.
Journal ArticleDOI
[2+2+2]-Cycloreversion reactions: a theoretical elucidation of thermodynamic and through-bond coupling effects on activation energies†‡
Dorota Sawicka,Yi Li,K. N. Houk +2 more
TL;DR: In this article, the [2+2++2]-cycloreversion reactions of cyclohexane and ten fused cycloshexanes were studied computationally with B3LYP/6-31G* and CASSCF methods.
Journal ArticleDOI
Electronic structure and photoelectron spectrum of 1,5,9-cyclododecatriyne
Journal ArticleDOI
[8+2] vs [4+2] Cycloadditions of Cyclohexadienamines to Tropone and Heptafulvenes-Mechanisms and Selectivities.
Xiangyang Chen,Mathias Kirk Thøgersen,Limin Yang,Limin Yang,Rune F. Lauridsen,Xiao-Song Xue,Xiao-Song Xue,Karl Anker Jørgensen,K. N. Houk +8 more
TL;DR: In this paper, the results of new experiments with heptafulvenes, containing diester and barbiturate substituents, were performed to elucidate the factors controlling higher-order cycloaddition pathways, including chemo-, regio-, and stereoselectivities.
Journal ArticleDOI
Isotopically Directed Symmetry Breaking and Enantioenrichment in Attrition-Enhanced Deracemization.
TL;DR: The origin of this iso-tope bias provides fundamental clues about overcoming stochastic behavior to direct the stereochemical outcome in attrition-enhanced deracemization processes and implications for the origin of biological homochirality are discussed.