K
K. N. Houk
Researcher at University of California, Los Angeles
Publications - 544
Citations - 19761
K. N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 68, co-authored 478 publications receiving 17032 citations. Previous affiliations of K. N. Houk include University of Pittsburgh & Leibniz University of Hanover.
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Journal ArticleDOI
Pressure-Induced Cycloadditions of Dicyanoacetylene to Strained Arenes: The Formation of Cyclooctatetraene, 9,10-Dihydronaphthalene, and Azulene Derivatives; A Degenerate [1,5] Sigmatropic Shift—Comparison between Theory and Experiment
Frank-Gerrit Klärner,Ralf Ehrhardt,Heinz Bandmann,Roland Boese,Dieter Bläser,K. N. Houk,Brett R. Beno +6 more
TL;DR: In this paper, a degenerate rearrangement consisting formally of a [1,5] vinyl shift in V or VI could be detected by their temp-dependent 1H NMR spectra.
Journal ArticleDOI
Structures of α-lithiomethanol and α-lithiomethylamine; and an ab initio study
TL;DR: LiCH2OH and LiCH2NH2 are suggested by ab initio molecular-orbital theory to posses a number of isomeric forms; in the lowest energy structures the hydroxy- or amino-group bridges the C-Li bond and extra stabilisation results as mentioned in this paper.
Posted ContentDOI
Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C-H Functionalization and Epoxidation of Tirandamycin Antibiotics
Rosa V. Espinoza,Kersti Caddell Haatveit,S. Wald Grossman,Jin Yi Tan,Caylie A. McGlade,Yogan Khatri,Sean A. Newmister,Jennifer J. Schmidt,Marc Garcia-Borràs,John Montgomery,K. N. Houk,David H. Sherman +11 more
TL;DR: The design and characterization of a toolbox of TamI biocatalysts, generated by mutations at Leu101, Leu244 and/or Leu295, that alter the native selectivity, step sequence and number of reactions catalyzed are reported.
Journal ArticleDOI
Unexpected Complexity in the Thermal [π2 + σ2 + σ2] Cycloaddition Reactions of Quadricyclane: Theory and Isotope Effects
Garth A. Jones,Michael J. Shephard,Michael N. Paddon-Row,Brett R. Beno,K. N. Houk,Kate Redmond,Barry K. Carpenter +6 more
TL;DR: In this article, a combined computational and experimental study has been performed on the thermal cycloaddition reactions of quadricyclane with acetylene, ethylene, dicyanoacetylene, and dimethyl acetylenedicarboxylate (DMAD).
Journal ArticleDOI
Cycloadditions of Cyclopentadiene and Cycloheptatriene with Tropones: All Endo-[6+4] Cycloadditions Are Ambimodal.
TL;DR: The cycloadditions of cyclopentadiene and cycloheptatriene with tropone are some of the earliest published examples of [6+4]-cycloaddition reactions.