K
K. N. Houk
Researcher at University of California, Los Angeles
Publications - 544
Citations - 19761
K. N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 68, co-authored 478 publications receiving 17032 citations. Previous affiliations of K. N. Houk include University of Pittsburgh & Leibniz University of Hanover.
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Journal ArticleDOI
Structure of trans-Di(3-iodobvenzoato)bis(1,3-diaminopropane)copper(II), C20H28CuI2N4O4
Journal ArticleDOI
De novo design of luciferases using deep learning
Andy Hsien-Wei Yeh,Christoffer Norn,Ya. I. Kipnis,Doug Tischer,S.J. Pellock,Declan Marshall Evans,Pengchen Ma,Gyu Rie Lee,Jason Z. Zhang,Ivan Anishchenko,Brian Coventry,Longxing Cao,Justas Dauparas,Samer Halabiya,Michelle DeWitt,Lauren Carter,K. N. Houk,D. Baker +17 more
TL;DR: In this article , a deep-learning-based hallucination approach was used to generate large numbers of idealized protein structures containing diverse pocket shapes and designed sequences that encode them, which can be used to design artificial luciferases that selectively catalyse the oxidative chemiluminescence of the synthetic luciferin substrates diphenylterazine 3 and 2-deoxycoelenterazine.
Journal ArticleDOI
Selectivity of (trifluoromethyl)chlorocarbene
Journal ArticleDOI
Ab initio calculation of the effects of cyano substituents on the Cope rearrangement
David A. Hrovat,Weston Thatcher Borden,Robert L. Vance,Nelson G. Rondan,K. N. Houk,Keiji Morokuma +5 more
Journal ArticleDOI
Acid-catalyzed aza-Diels-Alder reactions for the total synthesis of (+/-)-lapatin B.
Dominique Leca,Francesca Gaggini,Jérôme Yves Cassayre,Olivier Loiseleur,Susan N. Pieniazek,Jennifer A. R. Luft,K. N. Houk +6 more
TL;DR: A 5-step total synthesis of microfungal alkaloid (+/-)-lapatin B has been accomplished via a key 2-aza-Diels-Alder reaction and Brønsted acids catalyze the cycloaddition step and provide improved exo selectivity.