K
Kamaljit S. Balaggan
Researcher at New Cross Hospital
Publications - 36
Citations - 4321
Kamaljit S. Balaggan is an academic researcher from New Cross Hospital. The author has contributed to research in topics: Retina & Retinal detachment. The author has an hindex of 18, co-authored 33 publications receiving 3964 citations. Previous affiliations of Kamaljit S. Balaggan include UCL Institute of Ophthalmology & Moorfields Eye Hospital.
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Journal ArticleDOI
Effect of gene therapy on visual function in Leber's congenital amaurosis.
James W B Bainbridge,Alexander J. Smith,Susie S Barker,Scott J Robbie,Robert H. Henderson,Kamaljit S. Balaggan,Ananth C. Viswanathan,Graham E. Holder,Andrew Stockman,Nick Tyler,Simon M. Petersen-Jones,Shomi S. Bhattacharya,Adrian J. Thrasher,Fred W. Fitzke,Barrie J Carter,Gary S. Rubin,Anthony T. Moore,Robin R. Ali +17 more
TL;DR: Three young adult patients with early-onset, severe retinal dystrophy were administered subretinal injections of recombinant adeno-associated virus vector 2/2 expressing RPE65 complementary DNA (cDNA) under the control of a human R PE65 promoter.
Journal ArticleDOI
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
James W B Bainbridge,James W B Bainbridge,Manjit S Mehat,Venki Sundaram,Scott J Robbie,S. E. Barker,Caterina Ripamonti,Anastasios Georgiadis,Anastasios Georgiadis,Freya M. Mowat,Freya M. Mowat,Stuart G Beattie,Peter Gardner,Kecia L. Feathers,Vy Luong,Suzanne Yzer,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Ananth C. Viswanathan,Thomy de Ravel,Ingele Casteels,Graham E. Holder,Nick Tyler,Fred W. Fitzke,Richard G. Weleber,Marko Nardini,Marko Nardini,Anthony T. Moore,Anthony T. Moore,Debra A. Thompson,Simon M. Petersen-Jones,Michel Michaelides,Michel Michaelides,L. Ingeborgh van den Born,Andrew Stockman,Alexander J. Smith,Gary S. Rubin,Robin R. Ali,Robin R. Ali +38 more
TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
Journal ArticleDOI
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Kamaljit S. Balaggan,A MacNeil,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Alexander J. Smith,Prateek K. Buch,Robert E MacLaren,Patrick N. Anderson,S. E. Barker,Yanai Duran,CC Bartholomae,CC Bartholomae,Christof von Kalle,John R. Heckenlively,Christine Kinnon,Robin R. Ali,Adrian J. Thrasher +20 more
TL;DR: The high efficiency of gene transfer and expression mediated by lentiviruses can be harnessed in vivo without a requirement for vector integration and substantially reduces the risk of insertional mutagenesis.
Journal ArticleDOI
Comprehensive genomic access to vector integration in clinical gene therapy
Richard Gabriel,R Eckenberg,Anna Paruzynski,Cynthia C. Bartholomae,Ali Nowrouzi,Anne Arens,Steven J. Howe,Alessandra Recchia,Claudia Cattoglio,Wei Wang,Katrin Faber,Kerstin Schwarzwaelder,Romy Kirsten,Annette Deichmann,Claudia R. Ball,Kamaljit S. Balaggan,Rafael J. Yáñez-Muñoz,Robin R. Ali,H. Bobby Gaspar,Luca Biasco,Alessandro Aiuti,Daniela Cesana,Eugenio Montini,Luigi Naldini,Odile Cohen-Haguenauer,Fulvio Mavilio,Adrian J. Thrasher,Adrian J. Thrasher,Hanno Glimm,Christof von Kalle,William Saurin,Manfred Schmidt +31 more
TL;DR: A model to define genomic access to the viral integration site that provides optimal restriction motif combinations and minimizes the percentage of nonaccessible insertion loci is developed and a new nonrestrictive LAM-PCR approach is introduced.
Journal ArticleDOI
Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration.
Robert E MacLaren,Robert E MacLaren,Gurmit S. Uppal,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Adnan Tufail,Peter M. G. Munro,Andrew B. Milliken,Robin R. Ali,Gary S. Rubin,G. William Aylward,G. William Aylward,Lyndon da Cruz,Lyndon da Cruz +13 more
TL;DR: Autologous RPE transplantation can in principle restore vision in neovascular AMD, but surgical complications remain high.