K
Karen W. Makar
Researcher at Bill & Melinda Gates Foundation
Publications - 83
Citations - 5077
Karen W. Makar is an academic researcher from Bill & Melinda Gates Foundation. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 32, co-authored 83 publications receiving 4267 citations. Previous affiliations of Karen W. Makar include University of Washington & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.
Peggy P. Lee,David R. Fitzpatrick,Caroline Beard,Heidi K. Jessup,Sophie M. Lehar,Karen W. Makar,Mercedes Pérez-Melgosa,Marianne T. Sweetser,Mark S. Schlissel,Suzanne Nguyen,Sara Cherry,Jeff H. Tsai,Sean M. Tucker,William M. Weaver,Anne Kelso,Rudolf Jaenisch,Christopher B. Wilson +16 more
TL;DR: It is concluded that Dnmt1 and DNA methylation are required for the proper expression of certain genes that define fate and determine function in T cells.
Journal ArticleDOI
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
Ulrike Peters,Ulrike Peters,Shuo Jiao,Fredrick R. Schumacher,Carolyn M. Hutter,Carolyn M. Hutter,Aaron K. Aragaki,John A. Baron,Sonja I. Berndt,Stéphane Bézieau,Hermann Brenner,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Graham Casey,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,Lin Chen,Gerhard A. Coetzee,Simon G. Coetzee,David V. Conti,Keith R. Curtis,David Duggan,Todd L. Edwards,Charles S. Fuchs,Steven Gallinger,Edward Giovannucci,Stephanie M. Gogarten,Stephen B. Gruber,Robert W. Haile,Tabitha A. Harrison,Richard B. Hayes,Brian E. Henderson,Michael Hoffmeister,John L. Hopper,Thomas J. Hudson,Thomas J. Hudson,David J. Hunter,Rebecca D. Jackson,Sun Ha Jee,Mark A. Jenkins,Wei Hua Jia,Laurence N. Kolonel,Charles Kooperberg,Sébastien Küry,Andrea Z. LaCroix,Cathy C. Laurie,Cecelia A. Laurie,Loic Le Marchand,Mathieu Lemire,David K. Levine,Noralane M. Lindor,Yan Liu,Jing Ma,Karen W. Makar,Keitaro Matsuo,Polly A. Newcomb,Polly A. Newcomb,John D. Potter,John D. Potter,Ross L. Prentice,Conghui Qu,Thomas E. Rohan,Stephanie A. Rosse,Stephanie A. Rosse,Robert E. Schoen,Daniela Seminara,Martha J. Shrubsole,Xiao-Ou Shu,Martha L. Slattery,Darin Taverna,Stephen N. Thibodeau,Cornelia M. Ulrich,Emily White,Emily White,Yong-Bing Xiang,Brent W. Zanke,Yi Xin Zeng,Ben Zhang,Wei Zheng,Li Hsu +83 more
TL;DR: In a large genome-wide association study, polymorphisms close to nucleic acid binding protein 1 (which encodes a DNA-binding protein involved in DNA repair) with colorectal tumor risk and polymorphisms in laminin gamma 1, cyclin D2, and T-box 3 are associated.
Journal ArticleDOI
WHO International Standard for anti-SARS-CoV-2 immunoglobulin.
Paul A. Kristiansen,Mark Page,Valentina Bernasconi,Giada Mattiuzzo,Peter Dull,Karen W. Makar,Stanley A. Plotkin,Ivana Knezevic +7 more
Journal ArticleDOI
KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers
Amanda I. Phipps,Daniel D. Buchanan,Karen W. Makar,Aung Ko Win,John A. Baron,N. M. Lindor,John D. Potter,John D. Potter,Polly A. Newcomb +8 more
TL;DR: Kirsten Ras (KRAS)-mutated CRC was associated with statistically significantly poorer survival after diagnosis than KRAS-wild-type CRC and patterns were similar for overall survival.
Journal ArticleDOI
Meta-analysis of New Genome-wide Association Studies of Colorectal Cancer Risk
Ulrike Peters,Ulrike Peters,Carolyn M. Hutter,Li Hsu,Fredrick R. Schumacher,David V. Conti,Christopher S. Carlson,Christopher K. Edlund,Robert W. Haile,Steven Gallinger,Brent W. Zanke,Mathieu Lemire,Jagadish Rangrej,Raakhee Vijayaraghavan,Andrew T. Chan,Aditi Hazra,David J. Hunter,Jing Ma,Charles S. Fuchs,Edward Giovannucci,Peter Kraft,Yan Liu,Lin Chen,Shuo Jiao,Karen W. Makar,Darin Taverna,Stephen B. Gruber,Gad Rennert,Victor Moreno,Cornelia M. Ulrich,Cornelia M. Ulrich,Cornelia M. Ulrich,Michael O. Woods,Roger C. Green,Patrick S. Parfrey,Ross L. Prentice,Charles Kooperberg,Rebecca D. Jackson,Andrea Z. LaCroix,Bette J. Caan,Richard B. Hayes,Sonja I. Berndt,Stephen J. Chanock,Robert E. Schoen,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Bernd Frank,Stéphane Bézieau,Sébastien Küry,Martha L. Slattery,John L. Hopper,Mark A. Jenkins,Loic Le Marchand,Noralane M. Lindor,Polly A. Newcomb,Daniela Seminara,Thomas J. Hudson,Thomas J. Hudson,David Duggan,John D. Potter,John D. Potter,Graham Casey +62 more
TL;DR: The study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer and selected the most statistically significant single nucleotide polymorphisms for replication using ten independent studies.