D
Darin Taverna
Researcher at Halozyme Therapeutics
Publications - 27
Citations - 1697
Darin Taverna is an academic researcher from Halozyme Therapeutics. The author has contributed to research in topics: Genome-wide association study & Cancer. The author has an hindex of 15, co-authored 27 publications receiving 1484 citations. Previous affiliations of Darin Taverna include University of Michigan & Translational Genomics Research Institute.
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Journal ArticleDOI
Why are proteins marginally stable
TL;DR: It is found that the marginal stability of proteins is an inherent property of proteins due to the high dimensionality of the sequence space, without regard to protein function, and that marginal stability can result from neutral, non‐adaptive evolution.
Journal ArticleDOI
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
Ulrike Peters,Ulrike Peters,Shuo Jiao,Fredrick R. Schumacher,Carolyn M. Hutter,Carolyn M. Hutter,Aaron K. Aragaki,John A. Baron,Sonja I. Berndt,Stéphane Bézieau,Hermann Brenner,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Graham Casey,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,Lin Chen,Gerhard A. Coetzee,Simon G. Coetzee,David V. Conti,Keith R. Curtis,David Duggan,Todd L. Edwards,Charles S. Fuchs,Steven Gallinger,Edward Giovannucci,Stephanie M. Gogarten,Stephen B. Gruber,Robert W. Haile,Tabitha A. Harrison,Richard B. Hayes,Brian E. Henderson,Michael Hoffmeister,John L. Hopper,Thomas J. Hudson,Thomas J. Hudson,David J. Hunter,Rebecca D. Jackson,Sun Ha Jee,Mark A. Jenkins,Wei Hua Jia,Laurence N. Kolonel,Charles Kooperberg,Sébastien Küry,Andrea Z. LaCroix,Cathy C. Laurie,Cecelia A. Laurie,Loic Le Marchand,Mathieu Lemire,David K. Levine,Noralane M. Lindor,Yan Liu,Jing Ma,Karen W. Makar,Keitaro Matsuo,Polly A. Newcomb,Polly A. Newcomb,John D. Potter,John D. Potter,Ross L. Prentice,Conghui Qu,Thomas E. Rohan,Stephanie A. Rosse,Stephanie A. Rosse,Robert E. Schoen,Daniela Seminara,Martha J. Shrubsole,Xiao-Ou Shu,Martha L. Slattery,Darin Taverna,Stephen N. Thibodeau,Cornelia M. Ulrich,Emily White,Emily White,Yong-Bing Xiang,Brent W. Zanke,Yi Xin Zeng,Ben Zhang,Wei Zheng,Li Hsu +83 more
TL;DR: In a large genome-wide association study, polymorphisms close to nucleic acid binding protein 1 (which encodes a DNA-binding protein involved in DNA repair) with colorectal tumor risk and polymorphisms in laminin gamma 1, cyclin D2, and T-box 3 are associated.
Journal ArticleDOI
Meta-analysis of New Genome-wide Association Studies of Colorectal Cancer Risk
Ulrike Peters,Ulrike Peters,Carolyn M. Hutter,Li Hsu,Fredrick R. Schumacher,David V. Conti,Christopher S. Carlson,Christopher K. Edlund,Robert W. Haile,Steven Gallinger,Brent W. Zanke,Mathieu Lemire,Jagadish Rangrej,Raakhee Vijayaraghavan,Andrew T. Chan,Aditi Hazra,David J. Hunter,Jing Ma,Charles S. Fuchs,Edward Giovannucci,Peter Kraft,Yan Liu,Lin Chen,Shuo Jiao,Karen W. Makar,Darin Taverna,Stephen B. Gruber,Gad Rennert,Victor Moreno,Cornelia M. Ulrich,Cornelia M. Ulrich,Cornelia M. Ulrich,Michael O. Woods,Roger C. Green,Patrick S. Parfrey,Ross L. Prentice,Charles Kooperberg,Rebecca D. Jackson,Andrea Z. LaCroix,Bette J. Caan,Richard B. Hayes,Sonja I. Berndt,Stephen J. Chanock,Robert E. Schoen,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Bernd Frank,Stéphane Bézieau,Sébastien Küry,Martha L. Slattery,John L. Hopper,Mark A. Jenkins,Loic Le Marchand,Noralane M. Lindor,Polly A. Newcomb,Daniela Seminara,Thomas J. Hudson,Thomas J. Hudson,David Duggan,John D. Potter,John D. Potter,Graham Casey +62 more
TL;DR: The study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer and selected the most statistically significant single nucleotide polymorphisms for replication using ten independent studies.
Journal ArticleDOI
Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Fredrick R. Schumacher,Stephanie L. Schmit,Shuo Jiao,Christopher K. Edlund,Hansong Wang,Ben Zhang,Li Hsu,Shu Chen Huang,Christopher P. Fischer,John F. Harju,Gregory Idos,Flavio Lejbkowicz,Frank J. Manion,Kevin McDonnell,Caroline McNeil,Marilena Melas,Hedy S. Rennert,Wei Shi,Duncan C. Thomas,David Van Den Berg,Carolyn M. Hutter,Aaron K. Aragaki,Katja Butterbach,Bette J. Caan,Christopher S. Carlson,Stephen J. Chanock,Keith R. Curtis,Charles S. Fuchs,Manish Gala,Edward L. Giocannucci,Stephanie M. Gogarten,Richard B. Hayes,Brian E. Henderson,David J. Hunter,Rebecca D. Jackson,Laurence N. Kolonel,Charles Kooperberg,Sebastian Kury,Andrea Z. LaCroix,Cathy C. Laurie,Cecelia A. Laurie,Mathiew Lemire,David K. Levine,Jing Ma,Karen W. Makar,Conghui Qu,Darin Taverna,Cornelia M. Ulrich,Cornelia M. Ulrich,Cornelia M. Ulrich,Kana Wu,Suminori Kono,Dee W. West,Sonja I. Berndt,Stéphane Bézieau,Hermann Brenner,Peter T. Campbell,Andrew T. Chan,Jenny Chang-Claude,Gerhard A. Coetzee,David V. Conti,David Duggan,Jane C. Figueiredo,Barbara K. Fortini,Steven Gallinger,W. James Gauderman,Graham G. Giles,Roger C. Green,Robert W. Haile,Tabitha A. Harrison,Michael Hoffmeister,John L. Hopper,Thomas J. Hudson,Eric J. Jacobs,Motoki Iwasaki,Sun Ha Jee,Mark A. Jenkins,Wei Hua Jia,Amit Joshi,Li Li,N. M. Lindor,Keitaro Matsuo,Victor Moreno,Bhramar Mukherjee,Polly A. Newcomb,John D. Potter,Leon Raskin,Leon Raskin,Gad Rennert,Stephanie A. Rosse,Gianluca Severi,Robert E. Schoen,Daniela Seminara,Xiao-Ou Shu,Martha L. Slattery,Shoichiro Tsugane,Emily White,Yong-Bing Xiang,Brent W. Zanke,Wei Zheng,Loic Le Marchand,Graham Casey,Stephen B. Gruber,Ulrike Peters +103 more
TL;DR: Six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08 are described, providing additional insight into the underlying biological mechanisms of colorectal cancer and demonstrating the scientific value of large consortia-based genetic epidemiology studies.
Journal ArticleDOI
Why are proteins so robust to site mutations
TL;DR: In this article, the authors use a computational model with lattice proteins to demonstrate that protein robustness can result from population dynamics during the evolutionary process, and that sequence plasticity may be a characteristic of evolutionarily derived proteins and not necessarily a property of designed proteins.