B
Bernd Frank
Researcher at German Cancer Research Center
Publications - 44
Citations - 1725
Bernd Frank is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Breast cancer & Single-nucleotide polymorphism. The author has an hindex of 26, co-authored 44 publications receiving 1635 citations.
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Journal ArticleDOI
Meta-analysis of New Genome-wide Association Studies of Colorectal Cancer Risk
Ulrike Peters,Ulrike Peters,Carolyn M. Hutter,Li Hsu,Fredrick R. Schumacher,David V. Conti,Christopher S. Carlson,Christopher K. Edlund,Robert W. Haile,Steven Gallinger,Brent W. Zanke,Mathieu Lemire,Jagadish Rangrej,Raakhee Vijayaraghavan,Andrew T. Chan,Aditi Hazra,David J. Hunter,Jing Ma,Charles S. Fuchs,Edward Giovannucci,Peter Kraft,Yan Liu,Lin Chen,Shuo Jiao,Karen W. Makar,Darin Taverna,Stephen B. Gruber,Gad Rennert,Victor Moreno,Cornelia M. Ulrich,Cornelia M. Ulrich,Cornelia M. Ulrich,Michael O. Woods,Roger C. Green,Patrick S. Parfrey,Ross L. Prentice,Charles Kooperberg,Rebecca D. Jackson,Andrea Z. LaCroix,Bette J. Caan,Richard B. Hayes,Sonja I. Berndt,Stephen J. Chanock,Robert E. Schoen,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Bernd Frank,Stéphane Bézieau,Sébastien Küry,Martha L. Slattery,John L. Hopper,Mark A. Jenkins,Loic Le Marchand,Noralane M. Lindor,Polly A. Newcomb,Daniela Seminara,Thomas J. Hudson,Thomas J. Hudson,David Duggan,John D. Potter,John D. Potter,Graham Casey +62 more
TL;DR: The study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer and selected the most statistically significant single nucleotide polymorphisms for replication using ten independent studies.
Journal ArticleDOI
Characterization of gene-environment interactions for colorectal cancer susceptibility loci
Carolyn M. Hutter,Jenny Chang-Claude,Martha L. Slattery,Bethann M. Pflugeisen,Yi Lin,David Duggan,Hongmei Nan,Hongmei Nan,Mathieu Lemire,Jagadish Rangrej,Jane C. Figueiredo,Shuo Jiao,Tabitha A. Harrison,Yan Liu,Lin Chen,Deanna L. Stelling,Greg S. Warnick,Michael Hoffmeister,Sébastien Küry,Charles S. Fuchs,Edward Giovannucci,Aditi Hazra,Aditi Hazra,Aditi Hazra,Peter Kraft,David J. Hunter,Steven Gallinger,Brent W. Zanke,Hermann Brenner,Bernd Frank,Jing Ma,Cornelia M. Ulrich,Cornelia M. Ulrich,Emily White,Polly A. Newcomb,Charles Kooperberg,Andrea Z. LaCroix,Ross L. Prentice,Rebecca D. Jackson,Robert E. Schoen,Stephen J. Chanock,Sonja I. Berndt,Richard B. Hayes,Bette J. Caan,John D. Potter,John D. Potter,Li Hsu,Stéphane Bézieau,Andrew T. Chan,Thomas J. Hudson,Thomas J. Hudson,Ulrike Peters +51 more
TL;DR: Overall, the association of most CRC susceptibility loci identified in initial GWAS seems to be invariant to the other risk factors considered; however, the results suggest potential modification of the rs16892766 effect by vegetable consumption.
Journal ArticleDOI
Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk.
Bernd Frank,Justo Lorenzo Bermejo,Kari Hemminki,Christian Sutter,Barbara Wappenschmidt,Alfons Meindl,Marion Kiechle-Bahat,Peter Bugert,Rita K. Schmutzler,Claus R. Bartram,Barbara Burwinkel +10 more
TL;DR: The present study is the first to determine the impact of a CNV in a tumor suppressor gene on cancer risk, and found a significant association of the deletion variant with a decreased risk for both familial and high-risk familial BC.
Journal ArticleDOI
Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals
Paul Lochhead,Bernd Frank,Georgina L. Hold,Charles S. Rabkin,Michael T.H. Ng,Thomas L. Vaughan,Thomas L. Vaughan,Harvey A. Risch,Marilie D. Gammon,Jolanta Lissowska,Melanie N. Weck,Elke Raum,Heiko Müller,Thomas Illig,Norman Klopp,Alan Dawson,Kenneth E.L. McColl,Hermann Brenner,Wong Ho Chow,Emad M. El–Omar +19 more
TL;DR: The rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers.
Journal ArticleDOI
SNPs in ultraconserved elements and familial breast cancer risk.
Rongxi Yang,Bernd Frank,Kari Hemminki,Claus R. Bartram,Barbara Wappenschmidt,Christian Sutter,Marion Kiechle,Peter Bugert,Rita K. Schmutzler,Norbert Arnold,Bernhard H. F. Weber,Dieter Niederacher,Alfons Meindl,Barbara Burwinkel +13 more
TL;DR: This is the first study indicating that SNPs in UCEs might be associated with cancer risk, and two out of six SNPs showed an association with familial breast cancer risk.