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Seung Cheol Shim
Researcher at Chungnam National University
Publications - 82
Citations - 1722
Seung Cheol Shim is an academic researcher from Chungnam National University. The author has contributed to research in topics: Rheumatoid arthritis & Genome-wide association study. The author has an hindex of 20, co-authored 77 publications receiving 1348 citations. Previous affiliations of Seung Cheol Shim include Eulji University.
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Journal ArticleDOI
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Celi Sun,Julio E. Molineros,Loren L. Looger,Xu-jie Zhou,Kwangwoo Kim,Yukinori Okada,Jianyang Ma,Yuan-yuan Qi,Xana Kim-Howard,Prasenjeet Motghare,Krishna Bhattarai,Adam Adler,So Young Bang,Hye Soon Lee,Tae-Hwan Kim,Young Mo Kang,Chang Hee Suh,Won Tae Chung,Yong Beom Park,Jung Yoon Choe,Seung Cheol Shim,Yuta Kochi,Akari Suzuki,Michiaki Kubo,Takayuki Sumida,Kazuhiko Yamamoto,Shin-Seok Lee,Young-Jin Kim,Bok Ghee Han,Mikhail G. Dozmorov,Kenneth M. Kaufman,Jonathan D. Wren,John B. Harley,Nan Shen,Nan Shen,Kek Heng Chua,Hong Zhang,Sang Cheol Bae,Swapan K. Nath +38 more
TL;DR: Ten new SLE susceptibility loci are identified and the new loci share functional and ontological characteristics with previously reported loci and are possible drug targets for SLE therapeutics.
Journal ArticleDOI
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
Kwangwoo Kim,So Young Bang,Hye Soon Lee,Soo-Kyung Cho,Chan-Bum Choi,Yoon Kyoung Sung,Tae-Hwan Kim,Jae-Bum Jun,Dae Hyun Yoo,Young Mo Kang,Seong-Kyu Kim,Chang Hee Suh,Seung Cheol Shim,Shin-Seok Lee,Jisoo Lee,Won Tae Chung,Jung Yoon Choe,Hyoung Doo Shin,Jong-Young Lee,Bok Ghee Han,Swapan K. Nath,Steve Eyre,John Bowes,Dimitrios A. Pappas,Joel M. Kremer,Miguel A. González-Gay,Luis Rodriguez-Rodriguez,Lisbeth Ärlestig,Yukinori Okada,Dorothée Diogo,Katherine P. Liao,Elizabeth W. Karlson,Soumya Raychaudhuri,Solbritt Rantapää-Dahlqvist,Javier Martín,Lars Klareskog,Leonid Padyukov,Peter K. Gregersen,Jane Worthington,Jeff Greenberg,Robert M. Plenge,Sang Cheol Bae +41 more
TL;DR: This study demonstrates the advantage of dense-mapping and trans-ancestral analysis for identification of potentially causal SNPs and supports the importance of T cells in the pathogenesis and the fact of frequent overlap of risk loci among diverse autoimmune diseases.
Journal ArticleDOI
ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients
Philip Robinson,Mary-Ellen Costello,Paul Leo,Linda A. Bradbury,Kelly A. Hollis,Adrian Cortes,Seung-Hun Lee,Kyung Bin Joo,Seung Cheol Shim,Michael H. Weisman,Michael Ward,Xiaodong Zhou,Henri Jean Garchon,Gilles Chiocchia,Johannes C. Nossent,Johannes C. Nossent,Benedicte A. Lie,Øystein Førre,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Kari Laiho,Lei Jiang,Yu Liu,Xin Wu,Dirk Elewaut,Ruben Burgos-Vargas,Lianne S. Gensler,Simon Stebbings,Nigil Haroon,Juan Mulero,José Luis Fernández-Sueiro,Miguel A. Gonzalez-Gay,Carlos López-Larrea,Paul Bowness,Karl Gafney,J. S. H. Gaston,Dafna D. Gladman,Dafna D. Gladman,Proton Rahman,Walter P. Maksymowych,Huji Xu,Irene E. van der Horst-Bruinsma,C.T. Chou,C.T. Chou,Raphael Valle-Oñate,Maria Consuelo Romero-Sanchez,Inger Myrnes Hansen,Fernando Pimentel-Santos,Robert D. Inman,Javier Martin,Maxime Breban,David M. Evans,David M. Evans,John D. Reveille,Tae-Hwan Kim,B. Paul Wordsworth,Matthew A. Brown +57 more
Abstract: The association of endoplasmic reticulum aminopeptidase 2 (ERAP2) with ankylosing spondylitis (AS) was recently described in the large International Genetics of AS Consortium Immunochip study. Variants in ERAP2 have also been associated with inflammatory bowel disease, psoriasis, acute anterior uveitis and birdshot chorioretinopathy. Subsequent investigation demonstrated an association of ERAP2 with AS which was present when one conditioned on one of the two independent haplotypes of ERAP1 associated with AS or when HLA-B27-negative patients were analysed separately. These two analyses provide analogous evidence for the association of ERAP2 with AS in HLA-B27-negative cases because of the genetic interaction between HLA-B27 and the AS-associated ERAP1 variants in AS cases. ERAP1 and ERAP2 are located on chromosome 5q15 in the opposite orientation. The locus is challenging to analyse because of the strong linkage disequilibrium (LD) across the locus and the epistasis between ERAP1 and HLA-B alleles associated with AS. We therefore sought to investigate the association of ERAP2 with AS in HLA-B27-positive patients. This is of clinical importance because functional studies have demonstrated that the strongly AS-protective variant rs2248374 causes a functional ERAP2 protein knockout, because its G allele causes a loss of ERAP2 protein expression. There is also a variant of ERAP2 which changes its enzyme catalytic activity and specificity (rs2549782, K392A). Because this is in almost complete LD with rs2248374 (1000 Genomes D′=1.00, r2=0.90), it is almost never translated in vivo. Further, the very strong LD between these markers means that analysis of rs2549782 for association would yield results almost identical to the results for rs2248374 presented below. Therefore, it is of relevance to determine whether the association of ERAP2 with HLA-B27-negative disease is also found in HLA-B27-positive cases, since ERAP inhibition may offer a novel therapeutic for AS...
Journal ArticleDOI
A multicentre randomised controlled trial to compare the pharmacokinetics, efficacy and safety of CT-P10 and innovator rituximab in patients with rheumatoid arthritis
Dae Hyun Yoo,Chang Hee Suh,Seung Cheol Shim,Sławomir Jeka,Francisco Fidencio Cons-Molina,Paweł Hrycaj,Piotr Wiland,Eun Young Lee,Francisco G. Medina-Rodriguez,Pavel Shesternya,Sebastião Cezar Radominski,Marina Stanislav,Volodymyr Kovalenko,Dong Hyuk Sheen,Leysan Myasoutova,Mie Jin Lim,Jung Yoon Choe,Sang Joon Lee,Sung Young Lee,Taek Sang Kwon,Won Park +20 more
TL;DR: CT-P10 and RTX demonstrated equivalent pharmacokinetics and comparable efficacy, pharmacodynamics, immunogenicity and safety in patients with rheumatoid arthritis with inadequate responses or intolerances to antitumour necrosis factor agents.
Journal ArticleDOI
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans
Christopher J. Lessard,Satria Sajuthi,Jian Zhao,Kwangwoo Kim,John A. Ice,He Li,Hannah C. Ainsworth,Astrid Rasmussen,Jennifer A. Kelly,Miranda C. Marion,So Young Bang,Young Bin Joo,Jeongim Choi,Hye Soon Lee,Young Mo Kang,Chang Hee Suh,Won Tae Chung,Soo Kon Lee,Jung Yoon Choe,Seung Cheol Shim,Ji Hee Oh,Young-Jin Kim,Bok Ghee Han,Nan Shen,Hwee Siew Howe,Edward K. Wakeland,Quan Zhen Li,Yeong Wook Song,Patrick M. Gaffney,Marta E. Alarcón-Riquelme,Lindsey A. Criswell,Chaim O. Jacob,Robert P. Kimberly,Timothy J. Vyse,John B. Harley,Kathy L. Sivils,Sang Cheol Bae,Carl D. Langefeld,Betty P. Tsao +38 more
TL;DR: Using an unbiased genome‐wide association scan and replication analysis, it is sought to identify the genetic loci associated with SLE in a Korean population.