K
Karim Asehnoune
Researcher at Centre Hospitalier Universitaire de Nantes
Publications - 29
Citations - 4320
Karim Asehnoune is an academic researcher from Centre Hospitalier Universitaire de Nantes. The author has contributed to research in topics: Intensive care & Intensive care unit. The author has an hindex of 23, co-authored 29 publications receiving 3618 citations. Previous affiliations of Karim Asehnoune include University of Nantes & Anschutz Medical Campus.
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Journal ArticleDOI
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
Djillali Annane,Alain Renault,Christian Brun-Buisson,Bruno Mégarbane,Jean-Pierre Quenot,Shidasp Siami,Alain Cariou,Xavier Forceville,Carole Schwebel,Claude Martin,Jean-François Timsit,Benoit Misset,Mohamed Ali Benali,Gwenhael Colin,Bertrand Souweine,Karim Asehnoune,Emmanuelle Mercier,Loïc Chimot,C. Charpentier,Bruno François,Thierry Boulain,Franck Petitpas,Jean-Michel Constantin,Gilles Dhonneur,François Baudin,Alain Combes,Julien Bohé,Jean-François Loriferne,Roland Amathieu,Fabrice Cook,Michel Slama,Olivier Leroy,Gilles Capellier,Auguste Dargent,Tarik Hissem,Virginie Maxime,Eric Bellissant +36 more
TL;DR: In this trial involving patients with septic shock, 90‐day all‐cause mortality was lower among those who received hydrocortisone plus fludrocort isone or with drotrecogin alfa (activated), the combination of the three drugs, or their respective placebos.
Journal ArticleDOI
Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.
TL;DR: Results demonstrate that proximal events in TLR4 signaling, at or antecedent to IRAK-1 and IRAk-4 activation, are oxidant dependent and indicate that ROS can modulate NF-κB-dependent transcription through their involvement in earlyTLR4-mediated cellular responses.
Journal ArticleDOI
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)
Jean Reignier,Julie Boisramé-Helms,L. Brisard,Jean-Baptiste Lascarrou,Ali Ait Hssain,Nadia Anguel,Laurent Argaud,Karim Asehnoune,Pierre Asfar,Frédéric Bellec,Vlad Botoc,Anne Bretagnol,Hoang-Nam Bui,Emmanuel Canet,Daniel da Silva,Michael Darmon,Vincent Das,Jérôme Devaquet,Michel Djibré,Frédérique Ganster,Maité Garrouste-Orgeas,Stéphane Gaudry,Olivier Gontier,Claude Guérin,Bertrand Guidet,Christophe Guitton,Jean-Etienne Herbrecht,Jean-Claude Lacherade,Philippe Letocart,Frédéric Martino,Virginie Maxime,Emmanuelle Mercier,Jean-Paul Mira,Saad Nseir,Gaël Piton,Jean-Pierre Quenot,Jack Richecoeur,Jean-Philippe Rigaud,René Robert,Nathalie Rolin,Carole Schwebel,Michel Sirodot,François Tinturier,Didier Thevenin,Bruno Giraudeau,Amélie Le Gouge,Amélie Le Gouge,Hervé Dupont,Marc Pierrot,François Beloncle,Danièle Combaux,Romain Mercier,Hadrien Winiszewski,Gilles Capellier,Gilles Hilbert,Didier Gruson,Pierre Kalfon,Bertrand Souweine,Elizabeth Coupez,Jean-Damien Ricard,Jonathan Messika,François Bougerol,Pierre-Louis Declercq,Auguste Dargent,Audrey Large,Djillali Annane,Bernard Clair,Agnès Bonadona,Rebecca Hamidfar,Christian Richard,Mathieu Henry-Lagarrigue,Ahiem Yehia Yehia,Johanna Temime,Stephanie Barrailler,Raphael Favory,Erika Parmentier-Decrucq,Mercé Jourdain,Loredana Baboi,Marie Simon,Thomas Baudry,Mehran Monchi,Jérôme Roustan,Patrick Bardou,Alice Cottereau,Philippe Guiot,Noelle Brule,Mickael Landais,Antoine Roquilly,Thierry Boulain,Dalila Benzekri,Benoit Champigneulle,Jalel Tahiri,Gabriel Preda,Benoit Misset,Virginie Lemiale,Lara Zafrani,Muriel Fartoukh,Guillaume Thiery,Delphine Chatellier,Rémi Coudroy,Renaud Chouquer,Christine Brasse,Arnaud Delahaye,Luís Carlos de Souza Ferreira,Régine Vermesch,Stéphanie Chevalier,Charlotte Quentin,Quentin Maestraggi,Francis Schneider,Ferhat Meziani,Charles Cerf,Grégoire Trebbia,Charlotte Salmon-Gandonnière,Laetitia Bodet-Contentin +113 more
TL;DR: In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocallyoric parenteral nutrition.
Journal ArticleDOI
HMGB1 contributes to the development of acute lung injury after hemorrhage.
Jae-Yeol Kim,Jong Sung Park,Derek Strassheim,Ivor S. Douglas,Fernando Diaz del Valle,Karim Asehnoune,Sanchayita Mitra,Sang Hyun Kwak,Shingo Yamada,Ikuro Maruyama,Akitoshi Ishizaka,Edward Abraham +11 more
TL;DR: It is demonstrated that hemorrhage results in increasedHMGB1 expression in the lungs, primarily through neutrophil sources, and that HMGB1 participates in hemorrhage-induced acute lung injury.
Journal ArticleDOI
Early identification of patients at risk for difficult intubation in the intensive care unit: development and validation of the MACOCHA score in a multicenter cohort study.
Audrey De Jong,Nicolas Molinari,Nicolas Terzi,Nicolas Mongardon,Jean-Michel Arnal,Christophe Guitton,Bernard Allaouchiche,Catherine Paugam-Burtz,Jean-Michel Constantin,Jean-Yves Lefrant,Marc Leone,Laurent Papazian,Karim Asehnoune,Nicolas Maziers,Elie Azoulay,Gael Pradel,Boris Jung,Samir Jaber +17 more
TL;DR: In this article, the authors developed and validated a simplified score for identifying patients with difficult intubation in the ICU and to report related complications using data collected in a prospective multicenter study from 1,000 consecutive intubations from 42 ICUs.