K
Karin D. Rodland
Researcher at Pacific Northwest National Laboratory
Publications - 166
Citations - 11000
Karin D. Rodland is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Proteomics & Cancer. The author has an hindex of 46, co-authored 152 publications receiving 8139 citations. Previous affiliations of Karin D. Rodland include Reed College & Oregon Health & Science University.
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Journal ArticleDOI
Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods
Jintang He,Athena A. Schepmoes,Tujin Shi,Chaochao Wu,Thomas L. Fillmore,Yuqian Gao,Richard D. Smith,Wei-Jun Qian,Karin D. Rodland,Tao Liu,David G. Camp,Anshu Rastogi,Shyh-Han Tan,Wusheng Yan,Ahmed A. Mohamed,Wei Huang,Sreedatta Banerjee,Jacob Kagan,Sudhir Srivastava,David G. McLeod,David G. McLeod,Shiv Srivastava,Gyorgy Petrovics,Albert Dobi,Alagarsamy Srinivasan +24 more
TL;DR: It is proposed that the detection of both ERG transcriptional products with RNA-based assay, as well as protein products of ERG using PRISM-SRM assays, may be of clinical value in developing diagnostic and prognostic assays for prostate cancer given their sensitivity, specificity, and reproducibility.
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Antibody-independent Targeted Quantification of TMPRSS2-ERG Fusion Protein Products in Prostate Cancer
Jintang He,Xuefei Sun,Tujin Shi,Athena A. Schepmoes,Thomas L. Fillmore,Vladislav A. Petyuk,Fang Xie,Rui Zhao,Marina A. Gritsenko,Feng Q Yang,Naoki Kitabayashi,Sung-Suk Chae,Mark A. Rubin,Javed Siddiqui,John T. Wei,Arul M. Chinnaiyan,Wei-Jun Qian,Richard D. Smith,Jacob Kagan,Sudhir Srivastava,Karin D. Rodland,Tao Liu,David G. Camp +22 more
TL;DR: The results provide evidence that two distinct ERG protein isoforms are simultaneously expressed in TMPRSS2‐ERG positive samples as evidenced by the concomitant detection of two mutually exclusive peptides in two patient tumors and in the VCaP prostate cancer cell line.
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Targeted proteomic assays for quantitation of proteins identified by proteogenomic analysis of ovarian cancer.
Ehwang Song,Yuqian Gao,Chaochao Wu,Tujin Shi,Song Nie,Thomas L. Fillmore,Athena A. Schepmoes,Marina A. Gritsenko,Wei-Jun Qian,Richard D. Smith,Karin D. Rodland,Tao Liu +11 more
TL;DR: 98 SRM assays that have been thoroughly characterized according to the CPTAC Assay Characterization Guidance Document are reported, covering 70 proteins previously identified at the protein level in ovarian tumors.
Journal ArticleDOI
Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C.
TL;DR: Following TPA-induced depletion of protein kinase C activity, EGF stimulation of VL30 transcription and accumulation was unaffected while TPA effects were inhibited, implying that EGF and TPA act by separable pathways.
Journal ArticleDOI
An Integrative Analysis of Tumor Proteomic and Phosphoproteomic Profiles to Examine the Relationships Between Kinase Activity and Phosphorylation.
Osama A. Arshad,Vincent G. Danna,Vladislav A. Petyuk,Paul D. Piehowski,Tao Liu,Karin D. Rodland,Karin D. Rodland,Jason E. McDermott,Jason E. McDermott +8 more
TL;DR: Analysis of kinase activity in cancer integrating proteomic and phosphoproteomic data is provided, showing that phosphorylation at specific phosphosites is not well correlated with overall kinase abundance and individual kinases show a clear and statistically significant difference in correlation.