O
Osama A. Arshad
Researcher at Pacific Northwest National Laboratory
Publications - 11
Citations - 583
Osama A. Arshad is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 4, co-authored 7 publications receiving 274 citations.
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Journal ArticleDOI
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.
Suhas Vasaikar,Chen Huang,Xiaojing Wang,Vladislav A. Petyuk,Sara R. Savage,Bo Wen,Yongchao Dou,Yun Zhang,Zhiao Shi,Osama A. Arshad,Marina A. Gritsenko,Lisa J. Zimmerman,Jason E. McDermott,Therese R. W. Clauss,Ronald J. Moore,Rui Zhao,Matthew E. Monroe,Yi-Ting Wang,Matthew C. Chambers,Robbert J.C. Slebos,Ken S. Lau,Qianxing Mo,Li Ding,Matthew J. Ellis,Mathangi Thiagarajan,Christopher R. Kinsinger,Henry Rodriguez,Richard D. Smith,Karin D. Rodland,Karin D. Rodland,Daniel C. Liebler,Tao Liu,Bing Zhang,Akhilesh Pandey,Amanda G. Paulovich,Andrew N. Hoofnagle,D. R. Mani,Daniel W. Chan,David F. Ransohoff,David Fenyö,David L. Tabb,Douglas A. Levine,Emily S. Boja,Eric Kuhn,Forest M. White,Gordon Whiteley,Heng Zhu,Hui Zhang,Ie Ming Shih,Jasmin H. Bavarva,Jeffrey R. Whiteaker,Karen A. Ketchum,Karl R. Clauser,Kelly V. Ruggles,Kimberly Elburn,Linda Hannick,Mark A. Watson,Mauricio Oberti,Mehdi Mesri,Melinda E. Sanders,Melissa Borucki,Michael A. Gillette,Michael Snyder,Nathan Edwards,Negin Vatanian,Paul A. Rudnick,Peter B. McGarvey,Philip Mertins,R. Reid Townsend,Ratna R. Thangudu,Robert Rivers,Samuel H. Payne,Sherri R. Davies,Shuang Cai,Stephen E. Stein,Steven A. Carr,Steven J. Skates,Subha Madhavan,Tara Hiltke,Xian Chen,Yingming Zhao,Yue Wang,Zhen Zhang +82 more
TL;DR: Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens, which suggested glycolysis as a potential target to overcome the resistance of MSI-H tumors to immune checkpoint blockade.
Journal ArticleDOI
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
Jason E. McDermott,Osama A. Arshad,Vladislav A. Petyuk,Yi Fu,Marina A. Gritsenko,Therese R. W. Clauss,Ronald J. Moore,Athena A. Schepmoes,Rui Zhao,Matthew E. Monroe,Michael Schnaubelt,Chia-Feng Tsai,Samuel H. Payne,Chen Huang,Liang-Bo Wang,Steven M. Foltz,Matthew A. Wyczalkowski,Yige Wu,Ehwang Song,Molly Brewer,Mathangi Thiagarajan,Christopher R. Kinsinger,Ana I. Robles,Emily S. Boja,Henry Rodriguez,Daniel W. Chan,Bing Zhang,Zhen Zhang,Li Ding,Richard D. Smith,Tao Liu,Karin D. Rodland,Karin D. Rodland +32 more
TL;DR: Deep phosphoproteomics provides insights regarding the potential role of proliferation-induced replication stress in promoting the characteristic chromosomal instability of HGSC and suggests potential therapeutic targets for use in precision medicine trials.
Journal ArticleDOI
The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
Sunil K. Joshi,Tamilla Nechiporuk,Daniel Bottomly,Paul D. Piehowski,Julie A. Reisz,Janét Pittsenbarger,Andy Kaempf,Sara J. C. Gosline,Yi-Ting Wang,Joshua R. Hansen,Marina A. Gritsenko,Chelsea M. Hutchinson,Karl K. Weitz,Jamie Moon,Francesca Cendali,Thomas L. Fillmore,Chia-Feng Tsai,Athena A. Schepmoes,Tujin Shi,Osama A. Arshad,Jason E. McDermott,Özgün Babur,Kevin Watanabe-Smith,Emek Demir,Angelo D'Alessandro,Tao Liu,Cristina E. Tognon,Jeffrey W. Tyner,Shannon K. McWeeney,Karin D. Rodland,Karin D. Rodland,Brian J. Druker,Elie Traer +32 more
TL;DR: In this paper, the stepwise evolution of gilteritinib resistance in FLT3-mutated acute myeloid leukemia (AML) patients was studied.
Journal ArticleDOI
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans.
Bala S C Koritala,Bala S C Koritala,Kenneth I. Porter,Osama A. Arshad,Rajendra P. Gajula,Hugh D. Mitchell,Tarana Arman,Mugimane G. Manjanatha,Justin G. Teeguarden,Justin G. Teeguarden,Hans P. A. Van Dongen,Jason E. McDermott,Shobhan Gaddameedhi +12 more
TL;DR: In this paper, the authors investigated the potential mechanistic role that circadian disruption of cancer hallmark pathway genes may play in the increased cancer risk in shift workers and found that the simulated night shift schedule significantly altered the normal circadian rhythmicity of genes involved in cancer hallmark pathways.
Journal ArticleDOI
An Integrative Analysis of Tumor Proteomic and Phosphoproteomic Profiles to Examine the Relationships Between Kinase Activity and Phosphorylation.
Osama A. Arshad,Vincent G. Danna,Vladislav A. Petyuk,Paul D. Piehowski,Tao Liu,Karin D. Rodland,Karin D. Rodland,Jason E. McDermott,Jason E. McDermott +8 more
TL;DR: Analysis of kinase activity in cancer integrating proteomic and phosphoproteomic data is provided, showing that phosphorylation at specific phosphosites is not well correlated with overall kinase abundance and individual kinases show a clear and statistically significant difference in correlation.