K
Karin D. Rodland
Researcher at Pacific Northwest National Laboratory
Publications - 166
Citations - 11000
Karin D. Rodland is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Proteomics & Cancer. The author has an hindex of 46, co-authored 152 publications receiving 8139 citations. Previous affiliations of Karin D. Rodland include Reed College & Oregon Health & Science University.
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Journal ArticleDOI
An Improved Boosting to Amplify Signal with Isobaric Labeling (iBASIL) Strategy for Precise Quantitative Single-cell Proteomics.
Chia-Feng Tsai,Rui Zhao,Sarah M. Williams,Ronald J. Moore,Kendall Schultz,William B. Chrisler,Ljiljana Paša-Tolić,Karin D. Rodland,Richard D. Smith,Tujin Shi,Ying Zhu,Tao Liu +11 more
TL;DR: The improved Boosting to Amplify Signal with Isobaric Labeling (iBASIL) strategy allows for precise and robust quantitative single-cell proteomics, and highlights the importance of carefully evaluating and optimizing the boosting ratios and MS data acquisition conditions for achieving robust, comprehensive proteomic analysis of single cells.
Journal ArticleDOI
Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway.
Tujin Shi,Mario Niepel,Jason E. McDermott,Yuqian Gao,Carrie D. Nicora,William B. Chrisler,Lye Meng Markillie,Vladislav A. Petyuk,Richard D. Smith,Richard D. Smith,Karin D. Rodland,Peter K. Sorger,Wei-Jun Qian,H. Steven Wiley +13 more
TL;DR: The results suggest that the relative stoichiometry of core MAPK pathway proteins is very similar across different cell types, with cell-specific differences mostly restricted to variable amounts of feedback regulators and receptors.
Journal ArticleDOI
Evaluation of surface chemistries for antibody microarrays.
Shannon L. Seurynck-Servoss,Amanda M. White,Cheryl L. Baird,Karin D. Rodland,Richard C. Zangar +4 more
TL;DR: Although many slide types produce useful data, glass slides coated with aldehyde silane, poly-l-lysine, or aminosilane consistently produce superior results in the sandwich ELISA microarray analyses the authors performed.
Journal ArticleDOI
Analysis of the Salmonella typhimurium Proteome through Environmental Response toward Infectious Conditions
Joshua N. Adkins,Heather M. Mottaz,Angela D. Norbeck,Jean K. Gustin,Joanne Rue,Therese R. W. Clauss,Samuel O. Purvine,Karin D. Rodland,Fred Heffron,Richard D. Smith +9 more
TL;DR: This work used a liquid chromatography-mass spectrometry-based “bottom-up” proteomic approach to generate a more complete picture of the gene products that S. typhimurium synthesizes under typical laboratory conditions as well as in culture media that are known to induce expression of virulence genes.
Journal ArticleDOI
Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction.
Jing Wang,Jing Wang,Zihao Ma,Steven A. Carr,Philipp Mertins,Hui Zhang,Zhen Zhang,Daniel W. Chan,Matthew J. Ellis,Raymond R. Townsend,Richard D. Smith,Jason E. McDermott,Xian Chen,Amanda G. Paulovich,Emily S. Boja,Mehdi Mesri,Christopher R. Kinsinger,Henry Rodriguez,Karin D. Rodland,Daniel C. Liebler,Bing Zhang,Bing Zhang +21 more
TL;DR: The results demonstrate that proteome profiling outperforms transcriptome profiling for coexpression based gene function prediction and should be integrated if not preferred in gene function and human disease studies.