K
Karin Hahnke
Researcher at Max Planck Society
Publications - 15
Citations - 880
Karin Hahnke is an academic researcher from Max Planck Society. The author has contributed to research in topics: Immune system & RNase P. The author has an hindex of 11, co-authored 15 publications receiving 747 citations.
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Journal ArticleDOI
MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.
Anca Dorhoi,Marco Iannaccone,Maura Farinacci,Kellen C. Faé,Jörg Schreiber,Pedro Moura-Alves,Geraldine Nouailles,Hans-Joachim Mollenkopf,Dagmar Oberbeck-Müller,Sabine Jörg,Ellen Heinemann,Karin Hahnke,Delia Löwe,Franca Del Nonno,Delia Goletti,Rosanna Capparelli,Stefan H. E. Kaufmann +16 more
TL;DR: It is concluded that miR-223 directly targets the chemoattractants CXCL2, CCL3, and IL-6 in myeloid cells, and consequently, neutrophil-driven lethal inflammation in TB animals.
Journal ArticleDOI
Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis
Antje Kahnert,Peter Seiler,Maik Stein,Silke Bandermann,Karin Hahnke,Hans J. Mollenkopf,Stefan H. E. Kaufmann +6 more
TL;DR: It is emphasized that alternative activation deprives macrophages of control mechanisms that limit mycobacterial growth in vivo, thus supporting intracellular persistence of M. tuberculosis.
Journal ArticleDOI
Type I IFN signaling triggers immunopathology in tuberculosis‐susceptible mice by modulating lung phagocyte dynamics
Anca Dorhoi,Vladimir Yeremeev,Geraldine Nouailles,January Weiner,Sabine Jörg,Ellen Heinemann,Dagmar Oberbeck-Müller,Julia K. Knaul,Alexis Vogelzang,Stephen T. Reece,Karin Hahnke,Hans-Joachim Mollenkopf,Volker Brinkmann,Stefan H. E. Kaufmann +13 more
TL;DR: It is concluded that IFN I alters early innate events at the site of Mtb invasion leading to fatal immunopathology, furnish a mechanistic explanation for the detrimental role of IFn I in pulmonary TB and form a basis for understanding the complex roles ofIFN I in chronic inflammation.
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cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
Haipeng Liu,Haipeng Liu,Pedro Moura-Alves,Gang Pei,Hans-Joachim Mollenkopf,Robert Hurwitz,Xiangyang Wu,Fei Wang,Siyu Liu,Mingtong Ma,Yiyan Fei,Chenggang Zhu,Anne-Britta Koehler,Dagmar Oberbeck-Mueller,Karin Hahnke,Marion Klemm,Ute Guhlich-Bornhof,Baoxue Ge,Anne Tuukkanen,Michael Kolbe,Anca Dorhoi,Anca Dorhoi,Anca Dorhoi,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann +24 more
TL;DR: Endocytosis facilitates internalization of eCDNs, and the DNA sensor cGAS facilitates sensing of endocytosed CDNs, their perinuclear accumulation, and subsequent STING‐dependent release of type I IFN.
Journal ArticleDOI
Natural killer T-cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses
Marcus Niemeyer,Alexandre Darmoise,Hans-Joachim Mollenkopf,Karin Hahnke,Robert Hurwitz,Gurdyal S. Besra,Ulrich E. Schaible,Stefan H. E. Kaufmann +7 more
TL;DR: In this article, the gene expression profiles of natural killer T (NKT) cells were compared with other conventional T lymphocytes, including CD4+ T helper type 1 (Th1) and Th2 cytokines upon T-cell receptor ligation.