C
Céline Cruciani-Guglielmacci
Researcher at University of Paris
Publications - 63
Citations - 2152
Céline Cruciani-Guglielmacci is an academic researcher from University of Paris. The author has contributed to research in topics: Glucose homeostasis & Insulin. The author has an hindex of 22, co-authored 56 publications receiving 1857 citations. Previous affiliations of Céline Cruciani-Guglielmacci include Paris Diderot University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents
Stephen C. Benoit,Christopher J. Kemp,Carol F. Elias,William Abplanalp,James P. Herman,Stéphanie Migrenne,Anne Laure Lefevre,Céline Cruciani-Guglielmacci,Christophe Magnan,Fang Yu,Fang Yu,Kevin D. Niswender,Kevin D. Niswender,Boman G. Irani,William L. Holland,Deborah J. Clegg +15 more
TL;DR: Many of the deleterious effects of high-fat diets, specifically those enriched with palmitic acid, are CNS mediated via PKC-theta activation, resulting in reduced insulin activity.
Journal ArticleDOI
Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans
Leonore Wigger,Leonore Wigger,Céline Cruciani-Guglielmacci,A. Nicolas,Jessica Denom,Neïké Fernandez,Frédéric Fumeron,Pedro Marques-Vidal,Alain Ktorza,Werner Kramer,Anke M. Schulte,Hervé Le Stunff,Hervé Le Stunff,Robin Liechti,Ioannis Xenarios,Peter Vollenweider,Gérard Waeber,Ingo Uphues,Ronan Roussel,Christophe Magnan,Mark Ibberson,Bernard Thorens +21 more
TL;DR: Quantitative analysis of the plasma of mice from different genetic backgrounds led to the identification of a group of sphingolipids correlated with glucose tolerance and insulin secretion that may serve as early biomarkers of, and help identify, metabolic deregulation in the pathogenesis of T2D.
Journal ArticleDOI
Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.
Elise Dalmas,Elise Dalmas,Amine Toubal,Fawaz Alzaid,Katrina Blazek,Hayley L. Eames,Kristell Lebozec,Maria Pini,Maria Pini,Isabelle Hainault,Emilie Montastier,Emilie Montastier,Raphael G. P. Denis,Patricia Ancel,Patricia Ancel,Amélie Lacombe,Yin Ling,Yin Ling,Omran Allatif,Omran Allatif,Céline Cruciani-Guglielmacci,Sébastien André,Sébastien André,Nathalie Viguerie,Christine Poitou,Vladimir Stich,Alexandra Torcivia,Fabienne Foufelle,Serge Luquet,Judith Aron-Wisnewsky,Dominique Langin,Karine Clément,Irina A. Udalova,Nicolas Venteclef +33 more
TL;DR: It is demonstrated that mice lacking Irf5, when placed on a high-fat diet, show no difference in the growth of their epididymal white adipose tissue (epiWAT) but they show expansion of their subcutaneous white adiposes tissue, as compared to wild-type mice on the same diet, and it suggests that inhibition of IRF5 may promote a healthy metabolic state during this condition.
Journal ArticleDOI
Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.
Christophe Broca,Vincent Breil,Céline Cruciani-Guglielmacci,M. Manteghetti,Christine Rouault,Michel Derouet,Salwa W. Rizkalla,Bernard Pau,Pierre Petit,Gérard Ribes,Alain Ktorza,René Gross,Gérard Reach,Mohammed Taouis +13 more
TL;DR: Findings clearly demonstrate that ID-1101 can reduce insulin resistance through activation of the early steps of insulin signaling in peripheral tissues and in liver, making it a potentially very valuable therapeutic agent for diabetes treatment.
Journal ArticleDOI
Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels.
R. Wang,Céline Cruciani-Guglielmacci,Stéphanie Migrenne,Christophe Magnan,V. E. Cotero,Vanessa H. Routh +5 more
TL;DR: OA regulated three distinct subpopulations of ARC neurons in a glucose-dependent fashion, suggesting that an interaction between glucose and fatty acids regulates OA sensing in ARC neurons.