F
Fanny Aprahamian
Researcher at Institut Gustave Roussy
Publications - 31
Citations - 1245
Fanny Aprahamian is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 11, co-authored 22 publications receiving 549 citations. Previous affiliations of Fanny Aprahamian include Institut Universitaire de France & Université Paris-Saclay.
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Journal ArticleDOI
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice.
Clea Bárcena,Rafael Valdés-Mas,Pablo Mayoral,Cecilia Garabaya,Sylvère Durand,Francisco Rodríguez,María Teresa Fernández-García,Nuria Salazar,Nuria Salazar,Alicja Nogacka,Alicja Nogacka,Nuria Garatachea,Noélie Bossut,Fanny Aprahamian,Alejandro Lucia,Guido Kroemer,José M.P. Freije,Pedro M. Quirós,Carlos López-Otín +18 more
TL;DR: It is demonstrated that correction of the accelerated aging-associated intestinal dysbiosis is beneficial, suggesting the existence of a link between aging and the gut microbiota that provides a rationale for microbiome-based interventions against age-related diseases.
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Crizotinib-induced immunogenic cell death in non-small cell lung cancer
Peng Liu,Liwei Zhao,Jonathan Pol,Sarah Levesque,Adriana Petrazzuolo,Christina Pfirschke,Camilla Engblom,Steffen Rickelt,Takahiro Yamazaki,Kristina Iribarren,Laura Senovilla,Lucillia Bezu,Erika Vacchelli,Valentina Sica,Andréa Melis,Tiffany Martin,Lin Xia,Heng Yang,Qingqing Li,Jinfeng Chen,Sylvère Durand,Fanny Aprahamian,Deborah Lefevre,Sophie Broutin,Angelo Paci,Angelo Paci,Amaury Bongers,Veronique Minard-Colin,Eric Tartour,Laurence Zitvogel,Lionel Apetoh,Yuting Ma,Mikael J. Pittet,Oliver Kepp,Guido Kroemer +34 more
TL;DR: It is shown that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade and can exert their anticancer effect through indirect immune-dependent mechanism.
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Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade
Gladys Ferrere,Maryam Tidjani Alou,Peng Liu,Anne-Gaëlle Goubet,Marine Fidelle,Oliver Kepp,Sylvère Durand,Valerio Iebba,Aurélie Fluckiger,Romain Daillère,Cassandra Thelemaque,Claudia Grajeda-Iglesias,Carolina Alves Costa Silva,Fanny Aprahamian,Deborah Lefevre,Liwei Zhao,Bernhard Ryffel,Emeline Colomba,Monica Arnedos,Damien Drubay,Conrad Rauber,Didier Raoult,Francesco Asnicar,Tim D. Spector,Nicola Segata,Lisa Derosa,Guido Kroemer,Laurence Zitvogel +27 more
TL;DR: It is demonstrated that ketogenic diet induces a 3HB-mediated antineoplastic effect that relies on T cell–mediated cancer immunosurveillance.
Journal ArticleDOI
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Didac Carmona-Gutierrez,Andreas Zimmermann,Andreas Zimmermann,Katharina Kainz,Federico Pietrocola,Guo Chen,Silvia Maglioni,Alfonso Schiavi,Jihoon Nah,Sara Mertel,Christine B. Beuschel,Francesca Castoldi,Valentina Sica,Gert Trausinger,Reingard Raml,Cornelia Sommer,Sabrina Schroeder,Sebastian J. Hofer,Maria A. Bauer,Tobias Pendl,Jelena Tadic,Christopher Dammbrueck,Zehan Hu,Christoph Ruckenstuhl,Tobias Eisenberg,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Mahmoud Abdellatif,Simon Sedej,David Enot,David Enot,Heimo Wolinski,Jörn Dengjel,Oliver Kepp,Christoph Magnes,Frank Sinner,Frank Sinner,Thomas R. Pieber,Thomas R. Pieber,Junichi Sadoshima,Natascia Ventura,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +48 more
TL;DR: It is demonstrated that DMC extends lifespan and promotes health in multiple organisms by inducing autophagy and is identified in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine.
Journal ArticleDOI
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
José Manuel Bravo-San Pedro,José Manuel Bravo-San Pedro,Valentina Sica,Valentina Sica,Isabelle Martins,Isabelle Martins,Jonathan Pol,Jonathan Pol,Friedemann Loos,Friedemann Loos,Maria Chiara Maiuri,Maria Chiara Maiuri,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Gerasimos Anagnostopoulos,Mireia Niso-Santano,Fernando Aranda,Ignacio Ramírez-Pardo,Justine Lallement,Jessica Denom,Erwan Boedec,Erwan Boedec,Erwan Boedec,Philip Gorwood,Nicolas Ramoz,Karine Clément,Véronique Pelloux,Alili Rohia,François Pattou,Violeta Raverdy,Robert Caiazzo,Raphaël G. P. Denis,Patricia Boya,Lorenzo Galluzzi,Frank Madeo,Stéphanie Migrenne-Li,Céline Cruciani-Guglielmacci,Nektarios Tavernarakis,Nektarios Tavernarakis,Carlos López-Otín,Carlos López-Otín,Christophe Magnan,Guido Kroemer +46 more
TL;DR: neutralization of ACBP enhanced autophagy, stimulated fatty acid oxidation, inhibited appetite, reduced weight gain in the context of a high-fat diet or leptin deficiency, and accelerated weight loss in response to dietary changes.