K
Karine Rousseau
Researcher at Wellcome Trust Centre for Cell-Matrix Research
Publications - 37
Citations - 3105
Karine Rousseau is an academic researcher from Wellcome Trust Centre for Cell-Matrix Research. The author has contributed to research in topics: Mucin & Mucus. The author has an hindex of 23, co-authored 35 publications receiving 2756 citations. Previous affiliations of Karine Rousseau include Manchester Academic Health Science Centre & University College London.
Papers
More filters
Journal ArticleDOI
Structure and Function of the Polymeric Mucins in Airways Mucus
TL;DR: The airways mucus gel performs a critical function in defending the respiratory tract against pathogenic and environmental challenges and the roles of enormous, multifunctional, O-linked glycoproteins in health and disease are discussed.
Journal ArticleDOI
Muc5b is required for airway defence
Michelle G. Roy,Alessandra Livraghi-Butrico,Ashley A. Fletcher,Melissa M. McElwee,Scott E. Evans,Ryan M. Boerner,Samantha N. Alexander,Lindsey K. Bellinghausen,Alfred S. Song,Youlia Petrova,Michael J. Tuvim,Roberto Adachi,Irlanda Romo,Andrea S. Bordt,M. Gabriela Bowden,M. Gabriela Bowden,Joseph H. Sisson,Prescott G. Woodruff,David J. Thornton,Karine Rousseau,Maria Miguelina De La Garza,Seyed Javad Moghaddam,Harry Karmouty-Quintana,Michael R. Blackburn,Scott M. Drouin,C. William Davis,Kristy A. Terrell,Barbara R. Grubb,Wanda K. O'Neal,Sonia C. Flores,Adela Cota-Gomez,Catherine A. Lozupone,Jody Donnelly,Alan M. Watson,Corinne E. Hennessy,Rebecca C. Keith,Ivana V. Yang,Lea Barthel,Peter M. Henson,William J. Janssen,David A. Schwartz,Richard C. Boucher,Burton F. Dickey,Christopher M. Evans,Christopher M. Evans +44 more
TL;DR: It is shown that mouse Muc5b (but not MUC5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc 5ac is dispensable.
Journal ArticleDOI
Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis.
Karine Rousseau,Söbia Kauser,L E Pritchard,A Warhurst,Robert L. Oliver,Andrzej Slominski,Edward T. Wei,Anthony J. Thody,Desmond J. Tobin,Anne White +9 more
TL;DR: The release of POMC from skin cells and its functional activity at the MC‐1R highlight the importance of PomC processing as a key regulatory event in the skin.
Journal ArticleDOI
Expression of ErbB receptors and mucins in the airways of long term current smokers
R A O'Donnell,Audrey Richter,Jonathan Ward,Gilbert Angco,A Mehta,Karine Rousseau,Dallas M. Swallow,Stephen T. Holgate,Ratko Djukanovic,Donna E. Davies,Susan J. Wilson +10 more
TL;DR: It is suggested that long term current smoking induces enhanced epidermal growth factor receptor, ErbB3, and MUC5AC expression in vivo; these increases are not associated with the presence of neutrophilic inflammation.
Journal ArticleDOI
MUC5B Is the Major Mucin in the Gel Phase of Sputum in Chronic Obstructive Pulmonary Disease
Sara Kirkham,Umme Kolsum,Karine Rousseau,Dave Singh,Jørgen Vestbo,Jørgen Vestbo,David J. Thornton +6 more
TL;DR: There are differences in mucin amounts and properties between smokers with and without COPD, and there was a shift toward smaller mucins in the COPD group.