Joseph H. Sisson

TL;DR: It is shown that mouse Muc5b (but not MUC5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc 5ac is dispensable.

TL;DR: Critically ill patients managed with the Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility bundle spent three more days breathing without assistance, experienced less delirium, and were more likely to be mobilized during their ICU stay than patients treated with usual care.

TL;DR: A novel NO-dependent mechanism that upregulates ciliary motility in response to stimulation is demonstrated that modulates airway ciliary beating and was completely reversed by L-arginine or SNP but not by D- arginine.

TL;DR: It is concluded that all‐digital computerized CBF analysis correlates closely with standard video methods, markedly speeds up data analysis and provides new ways, including WFA, to analyse entire fields of motile cilia simultaneously.

TL;DR: The morphology and development of the pulmonary epithelial cells, their function with regard to host defence, alterations of themonary epithelium associated with airway diseases, and potential therapeutic implications for the treatment of respiratory diseases are reviewed.