M. Gabriela Bowden

TL;DR: A new mechanism of NET release that is very rapid and contributes to trapping and killing of S. aureus through a novel process of NET formation that did not require neutrophil lysis or even breach of the plasma membrane.

TL;DR: It is shown that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall–anchored staphylococcal proteins, including the lung inflammatory factor staphlyococcal protein A (Spa).

TL;DR: It is shown that mouse Muc5b (but not MUC5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc 5ac is dispensable.

TL;DR: Analysis of the crystal structures, along with mutational studies of both the protein and of the peptide, reveals that SdrG binds to its ligand with a dynamic "dock, lock, and latch" mechanism that represents a general mode of ligand binding for structurally related cell wall-anchored proteins of gram-positive bacteria.

TL;DR: Analysis of primary sequences of the Staphylococcus epidermidis surface (Ses) proteins indicates that they have a structural organization similar to the previously described cell-wall-anchored proteins from S. aureus and other Gram-positive cocci, and western blot analyses of early-logarithmic and late-stationary in vitro cultures suggest that different regulatory mechanisms control the expression of the Ses proteins.