K
Kathleen M. McAndrews
Researcher at University of Texas MD Anderson Cancer Center
Publications - 41
Citations - 2193
Kathleen M. McAndrews is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Tumor microenvironment & Medicine. The author has an hindex of 14, co-authored 31 publications receiving 906 citations. Previous affiliations of Kathleen M. McAndrews include Georgia Institute of Technology.
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Journal ArticleDOI
Generation and testing of clinical-grade exosomes for pancreatic cancer
Mayela Mendt,Sushrut Kamerkar,Hikaru Sugimoto,Kathleen M. McAndrews,Chia Chin Wu,Mihai Gagea,Sujuan Yang,Elena V.Rodriges Blanko,Qian Peng,Xiaoyan Ma,Joseph R. Marszalek,Anirban Maitra,Cassian Yee,Katayoun Rezvani,Elizabeth J. Shpall,Valerie S. LeBleu,Raghu Kalluri +16 more
TL;DR: A bioreactor-based, large-scale production of clinical-grade exosomes employing good manufacturing practice (GMP) standards is reported on, to confirm suppression of oncogenic Kras and an increase in the survival of several mouse models with pancreatic cancer.
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Clinical and therapeutic relevance of cancer-associated fibroblasts.
TL;DR: In this paper, the clinical relevance of CAFs is summarized with an emphasis on their value as prognosis factors and therapeutic targets, including how these complex bimodal functions evolve and are subjugated by neoplastic cells.
Journal ArticleDOI
Mechanisms associated with biogenesis of exosomes in cancer
TL;DR: Current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer are reviewed.
Journal ArticleDOI
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker.
Fernanda G. Kugeratski,Kelly Hodge,Sergio Lilla,Kathleen M. McAndrews,Xunian Zhou,Rosa F. Hwang,Sara Zanivan,Raghu Kalluri,Raghu Kalluri,Raghu Kalluri +9 more
TL;DR: In this article, the authors used an unbiased and quantitative proteomic approach based on super-stable isotope labeling with amino acids in cell culture (super-SILAC), coupled to high-resolution mass spectrometry.
Journal ArticleDOI
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.
Lisa M. Becker,Joyce T. O’Connell,Annie P. Vo,Margo P. Cain,Désirée Tampe,Lauren Bizarro,Lauren Bizarro,Hikaru Sugimoto,Hikaru Sugimoto,Anna K. McGow,John M. Asara,John M. Asara,Sara Lovisa,Kathleen M. McAndrews,Rafal Zielinski,Philip L. Lorenzi,Michael Zeisberg,Sughra Raza,Valerie S. LeBleu,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri +21 more
TL;DR: It is demonstrated that CAFs exhibit a metabolic shift toward lactate and pyruvate production and fuel biosynthetic pathways of cancer cells, and their breast cancer-promoting phenotype is partly mediated by oxygen-dependent epigenetic modifications.