Margo P. Cain

TL;DR: Current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells are presented.

TL;DR: It is demonstrated that CAFs exhibit a metabolic shift toward lactate and pyruvate production and fuel biosynthetic pathways of cancer cells, and their breast cancer-promoting phenotype is partly mediated by oxygen-dependent epigenetic modifications.

TL;DR: It is shown that VEGFA from the epithelium is required for a distinct endothelial cell (EC) population in the mouse lung, and this findings support a signaling role of AT1 cells and shed light on alveologenesis.

TL;DR: An intuitive method to construct quantitative ligand-receptor interactomes using single-cell RNA-sequencing data and its application to normal and Sendai virus-infected mouse lungs is described.

TL;DR: This study reconstructs the cellular makeup of the pronephric kidney and identifies conserved cells, segments, and expression profiles, and highlights significant conservation in podocytes, proximal and distal tubule cells and divergence in cellular composition underlying the evolution of the corticomedullary axis.