K
Katleen De Preter
Researcher at Ghent University
Publications - 161
Citations - 24504
Katleen De Preter is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 41, co-authored 150 publications receiving 21878 citations. Previous affiliations of Katleen De Preter include Katholieke Universiteit Leuven & Ghent University Hospital.
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Journal ArticleDOI
A p53 Drug Response Signature Identifies Prognostic Genes in High-Risk Neuroblastoma
Eveline Barbieri,Katleen De Preter,Mario Capasso,Peter Johansson,Tsz-Kwong Man,Zaowen Chen,Paris N Stowers,Gian Paolo Tonini,Franki Speleman,Jason M. Shohet +9 more
TL;DR: These findings further support the concept that oncogene-driven transcriptional networks opposing p53 activation are essential for the aggressive behavior and poor response to therapy of high-risk neuroblastoma.
Journal Article
A detailed inventory of DNA copy number alterations in four commonly used Hodgkin lymphoma cell lines
Tom Feys,Bruce Poppe,Katleen De Preter,Nadine Van Roy,Bruno Verhasselt,Pascale De Paepe,Anne De Paepe,Franki Speleman +7 more
Journal ArticleDOI
Application of laser capture microdissection in genetic analysis of neuroblastoma and neuroblastoma precursor cells.
Katleen De Preter,Jo Vandesompele,Pierre Heimann,Mark M Kockx,Mireille Van Gele,Jasmien Hoebeeck,Els De Smet,Martine Demarche,Genevieve Laureys,Nadine Van Roy,Anne De Paepe,Franki Speleman +11 more
TL;DR: Down-stream applications of laser capture microdissection (LCM) in the genetic analysis of neuroblastoma (NB) are described, with special focus on MYCN copy number determination using real-time quantitative polymerase chain reaction (Q-PCR), analysis of 1p-, 3p- and 11q-deletions using loss of heterozygosity analysis and Q- PCR expression analysis of microdissected normal neuroblast cells and NB cells.
Journal ArticleDOI
External oligonucleotide standards enable cross laboratory comparison and exchange of real-time quantitative PCR data
Joëlle Vermeulen,Filip Pattyn,Katleen De Preter,Liesbeth Vercruysse,Stefaan Derveaux,Pieter Mestdagh,Steve Lefever,Jan Hellemans,Frank Speleman,Jo Vandesompele +9 more
TL;DR: This study introduced and validated a workflow that employs universally applicable, quantifiable external oligonucleotide standards to address the lack of robust strategies for cross laboratory data comparison, and obtained a perfect concordance between expression values from eight different genes.
Journal ArticleDOI
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma.
Ali Rihani,Alan Van Goethem,Maté Ongenaert,Sara De Brouwer,Pieter-Jan Volders,Saurabh Agarwal,Katleen De Preter,Pieter Mestdagh,Jason M. Shohet,Franki Speleman,Jo Vandesompele,Tom Van Maerken +11 more
TL;DR: It is observed that these p53-regulated miRNAs inhibit the proliferation of neuroblastoma cells to varying degrees, with the most profound growth inhibition recorded for miR-182-5p.