S
Sara De Brouwer
Researcher at Ghent University
Publications - 5
Citations - 342
Sara De Brouwer is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 4, co-authored 5 publications receiving 289 citations.
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Journal ArticleDOI
The need for transparency and good practices in the qPCR literature
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Carl T. Wittwer,Peter Schjerling,Philip J. R. Day,Mónica Abreu,Begoña Aguado,Jean-François Beaulieu,Anneleen Beckers,Sara Bogaert,John A. Browne,Fernando Carrasco-Ramiro,Liesbeth Ceelen,Kate L. Ciborowski,Pieter Cornillie,Stephanie Coulon,Ann Cuypers,Sara De Brouwer,Leentje De Ceuninck,Jurgen De Craene,Hélène De Naeyer,Ward De Spiegelaere,Kato Deckers,Annelies Dheedene,Kaat Durinck,Margarida Ferreira-Teixeira,Annelies Fieuw,Jack M. Gallup,Sandra Gonzalo-Flores,Karen Goossens,Femke Heindryckx,Elizabeth Herring,Hans Hoenicka,Laura Icardi,Rolf Jaggi,Farzad Javad,Michael Karampelias,Frederick S. B. Kibenge,Molly J. T. Kibenge,Candy Kumps,Irina Lambertz,Tim Lammens,Amelia Markey,Peter Messiaen,Evelien Mets,Sofia Morais,Alberto Mudarra-Rubio,Justine K. Nakiwala,Hilde Nelis,Pål A. Olsvik,Claudina Perez-Novo,Michelle Plusquin,Tony Remans,Ali Rihani,Paulo Rodrigues-Santos,Pieter Rondou,Rebecca Sanders,Katharina Schmidt-Bleek,Kerstin Skovgaard,Karen Smeets,Laura Tabera,Stefan Toegel,Tim Van Acker,Wim Van den Broeck,Joni Van der Meulen,Mireille Van Gele,Gert Van Peer,Mario Van Poucke,Nadine Van Roy,Sarah Vergult,Joris Wauman,Marina Tshuikina-Wiklander,Erik Willems,Sara Zaccara,Fjoralba Zeka,Jo Vandesompele +83 more
TL;DR: Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information.
Journal ArticleDOI
Network Modeling of microRNA–mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN
Chi Yan Ooi,Daniel R. Carter,Bing Liu,Chelsea Mayoh,Anneleen Beckers,Amit Lalwani,Zsuzsanna Nagy,Sara De Brouwer,Bieke Decaesteker,Tzong-Tyng Hung,Murray D. Norris,Michelle Haber,Tao Liu,Katleen De Preter,Franki Speleman,Belamy B. Cheung,Glenn M. Marshall,Glenn M. Marshall +17 more
TL;DR: Novel tumorigenic miRNA gene networks and miR-204 as a tumor suppressor that regulates MYCN expression in neuroblastoma tumorigenesis are identified and novel miRNA-mRNA interaction networks are devised.
Journal ArticleDOI
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma.
Ali Rihani,Alan Van Goethem,Maté Ongenaert,Sara De Brouwer,Pieter-Jan Volders,Saurabh Agarwal,Katleen De Preter,Pieter Mestdagh,Jason M. Shohet,Franki Speleman,Jo Vandesompele,Tom Van Maerken +11 more
TL;DR: It is observed that these p53-regulated miRNAs inhibit the proliferation of neuroblastoma cells to varying degrees, with the most profound growth inhibition recorded for miR-182-5p.
Journal ArticleDOI
In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors.
Suzanne Vanhauwaert,Bieke Decaesteker,Sara De Brouwer,Carina Leonelli,Kaat Durinck,Pieter Mestdagh,Jo Vandesompele,Karen Sermon,Geertrui Denecker,Christophe Van Neste,Franki Speleman,Katleen De Preter +11 more
TL;DR: A novel ESC m(i)RNA signature stratifies neuroblastomas with poor prognosis, enabling the identification of therapy-resistant tumors and warrants for drug design targeted at FOXM1 or key components controlling this pathway.
Posted ContentDOI
SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma
Bieke Decaesteker,Amber Louwagie,Siebe Loontiens,Fanny De Vloed,Juliette Roels,Suzanne Vanhauwaert,Sara De Brouwer,Ellen Sanders,Geertrui Denecker,Eva D'haene,Stéphane Van Haver,Wouter Van Loocke,Jo Van Dorpe,David Creytens,Nadine Van Roy,Tim Pieters,Christophe Van Neste,Matthias Fischer,Pieter Van Vlierberghe,Stephen S. Roberts,Johannes H. Schulte,Sara Ek,Rogier Versteeg,Jan Koster,Johan van Nes,Katleen De Preter,Frank Speleman +26 more
TL;DR: It is proposed that adrenergic NB cells have co-opted the normal role of SOX11 as a crucial regulator of chromatin accessibility and cell identity.