K
Katleen De Preter
Researcher at Ghent University
Publications - 161
Citations - 24504
Katleen De Preter is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 41, co-authored 150 publications receiving 21878 citations. Previous affiliations of Katleen De Preter include Katholieke Universiteit Leuven & Ghent University Hospital.
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Journal ArticleDOI
Minimally invasive classification of paediatric solid tumours using reduced representation bisulphite sequencing of cell-free DNA: a proof-of-principle study
Ruben Van Paemel,Ruben Van Paemel,Andries De Koker,Charlotte Vandeputte,Lieke M. J. van Zogchel,Tim Lammens,Tim Lammens,Genevieve Laureys,Genevieve Laureys,Jo Vandesompele,Gudrun Schleiermacher,Mathieu Chicard,Nadine Van Roy,Ales Vicha,Godelieve A.M. Tytgat,Nico Callewaert,Katleen De Preter,Bram De Wilde,Bram De Wilde +18 more
TL;DR: This work provides proof-of-concept of histopathologic classification of paediatric tumours using cell-free reduced representation bisulphite sequencing (cf-RRBS) from retrospectively collected plasma and cerebrospinal fluid samples and determines the correct tumour type in 49 out of 60 samples.
Journal Article
Predicting outcomes for children with neuroblastoma.
Joëlle Vermeulen,Katleen De Preter,Pieter Mestdagh,Genevieve Laureys,Franki Speleman,Jo Vandesompele +5 more
TL;DR: In this article, the authors proposed new prognostic markers, including copy number aberrations, gene expression signatures, and epigenetic markers, for improved risk estimation at the time of diagnosis and to improve the choice of risk related therapy.
Journal ArticleDOI
Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
Fjoralba Zeka,Anneleen Decock,Alan Van Goethem,Katrien Vanderheyden,Fleur Demuynck,Tim Lammens,Tim Lammens,Hetty Helsmoortel,Joëlle Vermeulen,Rosa Noguera,Ana P. Berbegall,Valérie Combaret,Gudrun Schleiermacher,Genevieve Laureys,Genevieve Laureys,Alexander Schramm,Johannes H. Schulte,Johannes H. Schulte,Johannes H. Schulte,Sven Rahmann,Julie Bienertova Vasku,Pavel Mazánek,Marta Jeison,Shifra Ash,Michael D. Hogarty,Mirthala Moreno-Smith,Eveline Barbieri,Jason M. Shohet,Frank Berthold,Tom Van Maerken,Frank Speleman,Matthias Fischer,Matthias Fischer,Katleen De Preter,Pieter Mestdagh,Jo Vandesompele +35 more
TL;DR: Evaluation of serum miRNA variance in a model testing for tumor stage, MYCN status, age at diagnosis, and overall survival revealed tumor stage as the most significant factor impacting miRNA abundance in neuroblastoma serum.
Journal ArticleDOI
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma.
Johannes Fabian,Desiree Opitz,Kristina Althoff,Marco Lodrini,Marco Lodrini,Barbara Hero,Ruth Volland,Anneleen Beckers,Katleen De Preter,Anneleen Decock,Nitin Patil,Mohammed Abba,Annette Kopp-Schneider,Kathy Astrahantseff,Jasmin Wünschel,Jasmin Wünschel,Sebastian Pfeil,Maria Ercu,Annette Künkele,Jamie Hu,Jamie Hu,Theresa M Thole,Theresa M Thole,Leonille Schweizer,Gunhild Mechtersheimer,Daniel R. Carter,Belamy B. Cheung,Odilia Popanda,Andreas von Deimling,Jan Koster,Rogier Versteeg,Manfred Schwab,Glenn M. Marshall,Glenn M. Marshall,Frank Speleman,Ulrike Erb,Margot Zoeller,Heike Allgayer,Thorsten Simon,Matthias Fischer,Andreas E. Kulozik,Angelika Eggert,Olaf Witt,Olaf Witt,Johannes H. Schulte,Hedwig E. Deubzer +45 more
TL;DR: Results show CD9 is a critical and indirectly druggable suppressor of the invasion-metastasis cycle in neuroblastoma and combined treatment with HDAC/DNA methyltransferase inhibitors synergistically induced CD9 expression despite hypoxic, metabolic or cytotoxic stress.
Journal ArticleDOI
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development.
Anne-Catherine Dolens,Kaat Durinck,Marieke Lavaert,Joni Van der Meulen,Imke Velghe,Jelle De Medts,Karin Weening,Juliette Roels,Katrien De Mulder,Pieter-Jan Volders,Katleen De Preter,Tessa Kerre,Bart Vandekerckhove,Georges Leclercq,Jo Vandesompele,Pieter Mestdagh,Pieter Van Vlierberghe,Franki Speleman,Tom Taghon +18 more
TL;DR: This study suggests that human γδ T cell development is mediated by a stage‐specific Notch‐driven negative feedback loop through which miR‐17 temporally restricts BCL11B expression and provides functional insights into the developmental role of the disease‐associated genes BCL 11B and the miR–17–92 cluster in a human context.