K
Katleen De Preter
Researcher at Ghent University
Publications - 161
Citations - 24504
Katleen De Preter is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 41, co-authored 150 publications receiving 21878 citations. Previous affiliations of Katleen De Preter include Katholieke Universiteit Leuven & Ghent University Hospital.
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Journal ArticleDOI
The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease.
Bram De Wilde,Anneleen Beckers,Sven Lindner,Althoff Kristina,Katleen De Preter,Pauline Depuydt,Pieter Mestdagh,Tom Sante,Steve Lefever,Falk Hertwig,Falk Hertwig,Zhiyu Peng,Leming Shi,Sangkyun Lee,Elien Vandermarliere,Lennart Martens,Björn Menten,Alexander Schramm,Matthias Fischer,Matthias Fischer,Johannes H. Schulte,Jo Vandesompele,Frank Speleman +22 more
TL;DR: The further genomic characterization through exome sequencing and DNA copy number analysis of four of the currently available murine neuroblastoma model systems supports the validity of the tested mouse models for mechanistic and preclinical studies of human Neuroblastoma.
Journal ArticleDOI
Isolation of disseminated neuroblastoma cells from bone marrow aspirates for pretreatment risk assessment by array comparative genomic hybridization.
Mado Vandewoestyne,Candy Kumps,Katrien Swerts,Björn Menten,Tim Lammens,Jan Philippé,Katleen De Preter,Genevieve Laureys,Nadine Van Roy,Franki Speleman,Dieter Deforce +10 more
TL;DR: It is shown that the major recurrent DNA copy number alterations detected in primary neuroblastoma tumors can be detected, with high sensitivity and specificity, in the disseminated Neuroblastoma cells isolated from the bone marrow aspirates, using an array platform with high coverage for these regions.
Zipper plot : visualizing transcriptional activity of genomic regions
Francisco Avila Cobos,Jasper Anckaert,Pieter-Jan Volders,Celine Everaert,Dries Rombaut,Jo Vandesompele,Katleen De Preter,Pieter Mestdagh +7 more
TL;DR: The Zipper plot is developed, a novel visualization and analysis method that enables users to simultaneously interrogate thousands of human putative transcription start sites (TSSs) in relation to various features that are indicative for transcriptional activity.
Journal ArticleDOI
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Carolina de Carvalho Nunes,Lisa Depestel,Liselot Mus,Kaylee M. Keller,Louis Delhaye,Amber Louwagie,Muhammad Rishfi,Alex J Whale,Neesha Kara,Simon Andrews,Filemon S. Dela Cruz,Daoqi You,Armaan Siddiquee,Camila Takeno Cologna,Sam De Craemer,Emmy Dolman,Christoph Bartenhagen,Fanny De Vloed,K. Sanders,A. M. M. Eggermont,Sarah-Lee Bekaert,Wouter Van Loocke,Jan Willem Beck,Givani Dewyn,Siebe Loontiens,Gert Van Isterdael,Bieke Decaesteker,Laurentijn Tilleman,Filip Van Nieuwerburgh,Vanessa Vermeirssen,Christophe Van Neste,Bart Ghesquière,Steven Goossens,Sven Eyckerman,Katleen De Preter,Matthias Fischer,Jonathan Houseley,Jan J. Molenaar,Bram De Wilde,Stephen S. Roberts,Kaat Durinck,Franki Speleman +41 more
TL;DR: Combinatorial RRM2-CHK1 inhibition acts synergistic in high-risk neuroblastoma cell lines and patient-derived xenograft models, illustrating the therapeutic potential and identifying ribonucleotide reductase subunit M2 (RRM2) as a candidate dependency factor.
Posted ContentDOI
SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma
Bieke Decaesteker,Amber Louwagie,Siebe Loontiens,Fanny De Vloed,Juliette Roels,Suzanne Vanhauwaert,Sara De Brouwer,Ellen Sanders,Geertrui Denecker,Eva D'haene,Stéphane Van Haver,Wouter Van Loocke,Jo Van Dorpe,David Creytens,Nadine Van Roy,Tim Pieters,Christophe Van Neste,Matthias Fischer,Pieter Van Vlierberghe,Stephen S. Roberts,Johannes H. Schulte,Sara Ek,Rogier Versteeg,Jan Koster,Johan van Nes,Katleen De Preter,Frank Speleman +26 more
TL;DR: It is proposed that adrenergic NB cells have co-opted the normal role of SOX11 as a crucial regulator of chromatin accessibility and cell identity.