K
Kazuo Takahashi
Researcher at International University of Health and Welfare
Publications - 43
Citations - 1723
Kazuo Takahashi is an academic researcher from International University of Health and Welfare. The author has contributed to research in topics: Virus & Internal medicine. The author has an hindex of 13, co-authored 29 publications receiving 1642 citations.
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Journal ArticleDOI
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Yasushi Itoh,Kyoko Shinya,Maki Kiso,Tokiko Watanabe,Yoshihiro Sakoda,Masato Hatta,Yukiko Muramoto,Daisuke Tamura,Yuko Sakai-Tagawa,Takeshi Noda,Saori Sakabe,Masaki Imai,Yasuko Hatta,Shinji Watanabe,Chengjun Li,Shinya Yamada,Ken Fujii,Shin Murakami,Hirotaka Imai,Satoshi Kakugawa,Mutsumi Ito,Ryo Takano,Kiyoko Iwatsuki-Horimoto,Masayuki Shimojima,Taisuke Horimoto,Hideo Goto,Kei Takahashi,Akiko Makino,Hirohito Ishigaki,Misako Nakayama,Masatoshi Okamatsu,Kazuo Takahashi,David Warshauer,Peter A. Shult,Reiko Saito,Hiroshi Suzuki,Yousuke Furuta,Makoto Yamashita,Keiko Mitamura,Kunio Nakano,Morio Nakamura,Rebecca A. Brockman-Schneider,Hiroshi Mitamura,Masahiko Yamazaki,Norio Sugaya,M. Suresh,Makoto Ozawa,Makoto Ozawa,Gabriele Neumann,James E. Gern,Hiroshi Kida,Kazumasa Ogasawara,Yoshihiro Kawaoka +52 more
TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.
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Direct Metagenomic Detection of Viral Pathogens in Nasal and Fecal Specimens Using an Unbiased High-Throughput Sequencing Approach
Shota Nakamura,Cheng-Song Yang,Naomi Sakon,Mayo Ueda,Takahiro Tougan,Akifumi Yamashita,Naohisa Goto,Kazuo Takahashi,Teruo Yasunaga,Kazuyoshi Ikuta,Tetsuya Mizutani,Yoshiko Okamoto,Michihira Tagami,Ryoji Morita,Norihiro Maeda,Jun Kawai,Yoshihide Hayashizaki,Yoshiyuki Nagai,Toshihiro Horii,Tetsuya Iida,Takaaki Nakaya +20 more
TL;DR: The results suggest that the unbiased high-throughput sequencing approach is useful for directly detecting pathogenic viruses without advance genetic information, and could be useful for the earlier discovery of novel emerging viruses and bioterrorism, which are difficult to detect with conventional procedures.
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Impact of Genotype-Specific Herd Immunity on the Circulatory Dynamism of Norovirus: A 10-Year Longitudinal Study of Viral Acute Gastroenteritis
Naomi Sakon,Kenji Yamazaki,Keiko Nakata,Daiki Kanbayashi,Tomoko Yoda,Masanobu Mantani,Tetsuo Kase,Kazuo Takahashi,Jun Komano +8 more
TL;DR: Evidence at both the facility and individual levels indicated that genotype-specific herd immunity lasted long enough to influence the endemic norovirus genotype in the next season, indicating that norov virus circulates through human populations in a uniquely dynamic fashion.
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Mutation Analysis of 2009 Pandemic Influenza A(H1N1) Viruses Collected in Japan during the Peak Phase of the Pandemic
Jean-Étienne Morlighem,Shintaro Aoki,Mami Kishima,Mitsue Hanami,Chihiro Ogawa,Amadu Jalloh,Yukari Takahashi,Yuki Kawai,Satomi Saga,Eiji Hayashi,Toshiaki Ban,Shinyu Izumi,Akira Wada,Masayuki Mano,Megumu Fukunaga,Yoshiyuki Kijima,Masashi Shiomi,Kaoru Inoue,Takeshi Hata,Yukihiro Koretsune,Koichiro Kudo,Yuji Himeno,Aizan Hirai,Kazuo Takahashi,Yuko Sakai-Tagawa,Kiyoko Iwatsuki-Horimoto,Yoshihiro Kawaoka,Yoshihide Hayashizaki,Toshihisa Ishikawa +28 more
TL;DR: A pandemic influenza A(H1N1) virus infection quickly circulated worldwide in 2009 and the first case was reported in Japan in May 2009, one month after its outbreak in Mexico as mentioned in this paper.
Journal ArticleDOI
Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients
Yohei Watanabe,Yohei Watanabe,Yasuha Arai,Tomo Daidoji,Norihito Kawashita,Madiha S. Ibrahim,Emad Mohamed Elgendy,Hiroaki Hiramatsu,Ritsuko Kubota-Koketsu,Tatsuya Takagi,Takeomi Murata,Kazuo Takahashi,Yoshinobu Okuno,Takaaki Nakaya,Yasuo Suzuki,Kazuyoshi Ikuta +15 more
TL;DR: Using reverse genetics, it is found that increases in both human receptor specificity and the HA pH threshold for membrane fusion were necessary to facilitate replication of the virus variants in human airway epithelia and that multiple HA mutations were actually selected in H5N1-infected patients and that H4N1 variants with some of these HA mutations had increased human-type receptor Specificity and increased HA membrane fusion activity.