K
Keiran Raine
Researcher at Wellcome Trust Sanger Institute
Publications - 90
Citations - 46730
Keiran Raine is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Mutation & Cancer. The author has an hindex of 53, co-authored 83 publications receiving 38869 citations. Previous affiliations of Keiran Raine include Wellcome Trust & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Erratum: The Life History of 21 Breast Cancers (Cell 149 (994-1007))
Serena Nik-Zainal,P Van Loo,David C. Wedge,Ludmil B. Alexandrov,Christopher Greenman,King Wai Lau,Keiran Raine,David Jones,John Marshall,Manasa Ramakrishna,Adam Shlien,Susanna L. Cooke,Jonathon Hinton,Andy Menzies,Lucy Stebbings,Catherine Leroy,Mingming Jia,Richard Rance,Laura Mudie,Steve Gamble,Phil Stephens,Stuart McLaren,P. S. Tarpey,Elli Papaemmanuil,Helen Davies,Ignacio Varela,David J. McBride,Graham R. Bignell,Kenric Leung,Adam Butler,Jon W. Teague,S. Martin,Göran Jönsson,Odette Mariani,Sandrine Boyault,Penelope Miron,Aquila Fatima,Anita Langerød,Aparicio Sajr.,Andrew Tutt,Anieta M. Sieuwerts,Åke Borg,Gilles Thomas,Anne Vincent Salomon,Andrea L. Richardson,Anne Lise Børresen-Dale,P A Futreal,Michael R. Stratton,Peter J. Campbell +48 more
Journal ArticleDOI
Polygenic in vivo validation of cancer mutations using transposons
Su K.it Chew,Dong Lu,Dong Lu,Lia S. Campos,Kenneth L. Scott,Abdel Saci,Juexuan Wang,Adam Collinson,Adam Collinson,Keiran Raine,Jonathan Hinton,Jon W. Teague,David T. Jones,Andrew Menzies,Adam Butler,John Gamble,Sarah O’Meara,Stuart McLaren,Lynda Chin,Pentao Liu,P. Andrew Futreal,P. Andrew Futreal +21 more
TL;DR: A mouse model is described that allows multiple cancer mutations to be validated in each animal line using transposons, presenting a useful, generalised and efficient means for animal validation of cancer genes.
Journal ArticleDOI
The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients
Jyoti Nangalia,Charles E. Massie,E. Joanna Baxter,Francesca L. Nice,Gunes Gundem,David C. Wedge,Edward Avezov,Juan Li,Karoline Kollmann,David G. Kent,Athar Aziz,Anna L. Godfrey,Jonathan Hinton,Inigo Martincorena,Peter Van Loo,Amy V. Jones,Paola Guglielmelli,Patrick S. Tarpey,Heather P. Harding,John D Fitzpatrick,Calum T Goudie,Christina A. Ortmann,Stephen J. Loughran,Keiran Raine,David T. Jones,Adam Butler,Jon W. Teague,Sarah O’Meara,Stuart McLaren,Michele Bianchi,Yvonne Silber,Danai Dimitropolou,David Bloxham,Laura Mudie,Mark Maddison,Ben Robinson,Clodagh Keohane,Cathy MacLean,Kate Hill,Kim Orchard,Sudhir Tauro,Ming-Qing Du,Mel Greaves,David G. Bowen,Brian J. P. Huntly,Claire N. Harrison,Nicholas C.P. Cross,David Ron,Alessandro M. Vannucchi,Elli Papaemmanuil,Peter J. Campbell,Anthony R. Green +51 more
TL;DR: Novel somatic mutations in calreticulin ( CALR) were identified by exome sequencing in the majority (26/31) of JAK2 or MPL unmutated patients, and 97% of patients harbored a mutation in 1 of these 3 genes.
Journal ArticleDOI
The Genomic Landscape of TEL-AML1+ (ETV6-RUNX1) Acute Lymphoblastic Leukaemia
Elli Papaemmanuil,Inmaculada Rapado,Anthony M. Ford,Keiran Raine,Jonathan Hinton,David T. Jones,John Marshall,Laura Mudie,Jan Zuna,Giovanni Cazzaniga,Helena Kempski,Maria S Pombo de Oliveira,Michael R. Stratton,P. Andrew Futreal,Peter J. Campbell,Mel Greaves +15 more
TL;DR: An extensive genomic analysis of 58 cases with diagnostic (leukaemic) cell DNA paired with matched, remission sample as a source of constitutive DNA provided new insights into the molecular pathology of ETV6-RUNX1 + ALL and presents the first detailed characterisation of the genomic landscape of this ALL subtype.