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Keiran Raine
Researcher at Wellcome Trust Sanger Institute
Publications - 90
Citations - 46730
Keiran Raine is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Mutation & Cancer. The author has an hindex of 53, co-authored 83 publications receiving 38869 citations. Previous affiliations of Keiran Raine include Wellcome Trust & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
The Life History of 21 Breast Cancers
Serena Nik-Zainal,Peter Van Loo,Peter Van Loo,Peter Van Loo,David C. Wedge,Ludmil B. Alexandrov,Christopher Greenman,Christopher Greenman,King Wai Lau,Keiran Raine,David T. Jones,John L. Marshall,Manasa Ramakrishna,Adam Shlien,Susanna L. Cooke,Jonathan Hinton,Andrew Menzies,Lucy Stebbings,Catherine Leroy,Mingming Jia,Richard Rance,Laura Mudie,Stephen J. Gamble,Philip J. Stephens,Stuart McLaren,Patrick S. Tarpey,Elli Papaemmanuil,Helen Davies,Ignacio Varela,David J. McBride,Graham R. Bignell,Kenric Leung,Adam Butler,Jon W. Teague,Sancha Martin,Göran Jönsson,Odette Mariani,Sandrine Boyault,Penelope Miron,Aquila Fatima,Anita Langerød,Samuel Aparicio,Andrew Tutt,Anieta M. Sieuwerts,Åke Borg,Gilles Thomas,Anne Vincent Salomon,Andrea L. Richardson,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell +54 more
TL;DR: Algorithms were developed to decipher this narrative and applied them to 21 breast cancers, finding that expansion of the dominant subclone to an appreciable mass may represent the final rate-limiting step in a breast cancer's development, triggering diagnosis.
Journal ArticleDOI
Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma
Ignacio Varela,Patrick S. Tarpey,Keiran Raine,Dachuan Huang,Choon Kiat Ong,Philip J. Stephens,Helen Davies,David T. Jones,Meng-Lay Lin,Jon W. Teague,Graham R. Bignell,Adam Butler,Juok Cho,Gillian L. Dalgliesh,Danushka Galappaththige,Christopher Greenman,Claire Hardy,Mingming Jia,Calli Latimer,King Wai Lau,John Marshall,Stuart McLaren,Andrew Menzies,Laura Mudie,Lucy Stebbings,David A. Largaespada,Lodewyk F. A. Wessels,Stéphane Richard,Stéphane Richard,Richard J. Kahnoski,John Anema,David A. Tuveson,Pedro A. Perez-Mancera,Ville Mustonen,Andrej Fischer,Andrej Fischer,David J. Adams,Alistair G. Rust,Waraporn Chan-on,Chutima Subimerb,Karl Dykema,Kyle A. Furge,Peter J. Campbell,Bin Tean Teh,Bin Tean Teh,Michael R. Stratton,P. Andrew Futreal +46 more
TL;DR: The protein coding exome is sequenced in a series of primary ccRCC and the identification of the SWI/SNF chromatin remodelling complex gene PBRM1 is reported as a second majorccRCC cancer gene, with truncating mutations in 41% (92/227) of cases.
Journal ArticleDOI
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
Elli Papaemmanuil,Mario Cazzola,Jacqueline Boultwood,Luca Malcovati,Paresh Vyas,David T. Bowen,Andrea Pellagatti,J. S. Wainscoat,Eva Hellström-Lindberg,Carlo Gambacorti-Passerini,Anna L. Godfrey,I. Rapado,Ana Cvejic,Ana Cvejic,Richard Rance,C. McGee,Peter R. Ellis,Laura Mudie,Phil Stephens,Stuart McLaren,Charles E. Massie,Patrick S. Tarpey,Ignacio Varela,Serena Nik-Zainal,Helen Davies,Adam Shlien,David T. Jones,Keiran Raine,Jonathon Hinton,Adam Butler,Jon W. Teague,E J Baxter,Joannah Score,Anna Gallì,M.G. Della Porta,Erica Travaglino,Michael J. Groves,Sudhir Tauro,Nikhil C. Munshi,Nikhil C. Munshi,KC Anderson,Adel K. El-Naggar,Andrej Fischer,Andrej Fischer,Ville Mustonen,Alan J. Warren,Nicholas C.P. Cross,Anthony R. Green,P A Futreal,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +51 more
TL;DR: Mutations in SF3B1 implicate abnormalities of messenger RNA splicing in the pathogenesis of myelodysplastic syndromes and were associated with down-regulation of key gene networks, including core mitochondrial pathways.
Journal ArticleDOI
Universal Patterns of Selection in Cancer and Somatic Tissues
Inigo Martincorena,Keiran Raine,Moritz Gerstung,Kevin J. Dawson,Kerstin Haase,Peter Van Loo,Peter Van Loo,Helen Davies,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +10 more
TL;DR: This work adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types, allowing exome-wide enumeration of all driver coding mutations, including outside known cancer genes.