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Keiran Raine
Researcher at Wellcome Trust Sanger Institute
Publications - 90
Citations - 46730
Keiran Raine is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Mutation & Cancer. The author has an hindex of 53, co-authored 83 publications receiving 38869 citations. Previous affiliations of Keiran Raine include Wellcome Trust & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
Bettina Meier,Susanna L. Cooke,Joerg Weiss,Aymeric P. Bailly,Ludmil B. Alexandrov,John Marshall,Keiran Raine,Mark Maddison,Elizabeth Anderson,Michael R. Stratton,Anton Gartner,Peter J. Campbell +11 more
TL;DR: Experimental model systems combined with genome sequencing can recapture and mechanistically explain mutational signatures associated with human disease.
Journal ArticleDOI
cgpCaVEManWrapper: Simple Execution of CaVEMan in Order to Detect Somatic Single Nucleotide Variants in NGS Data.
David T. Jones,Keiran Raine,Helen Davies,Patrick S. Tarpey,Adam Butler,Jon W. Teague,Serena Nik-Zainal,Peter J. Campbell +7 more
TL;DR: A simple one‐shot run of cgpCaVEManWrapper is described and a more in‐depth implementation suited to large‐scale compute farms is described, which runs the CaV EMan algorithm and additional downstream post‐hoc filters.
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Extensive heterogeneity in somatic mutation and selection in the human bladder
Andrew R. J. Lawson,Federico Abascal,Tim H. H. Coorens,Yvette Hooks,Laura O’Neill,Calli Latimer,Keiran Raine,Mathijs A. Sanders,Mathijs A. Sanders,Anne Y. Warren,Krishnaa T. Mahbubani,Bethany Bareham,Tim Butler,Luke M. R. Harvey,Alex Cagan,Andrew Menzies,Luiza Moore,Luiza Moore,Alexandra Colquhoun,William Turner,Benjamin Thomas,Benjamin Thomas,Vincent Gnanapragasam,Nicholas Williams,Doris Rassl,Harald Vöhringer,Sonia Zumalave,Jyoti Nangalia,Jose M. C. Tubio,Jose M. C. Tubio,Moritz Gerstung,Kourosh Saeb-Parsy,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell,Thomas J. Mitchell,Thomas J. Mitchell,Inigo Martincorena +37 more
TL;DR: A rich landscape of mutational processes and selection in normal urothelium with large heterogeneity across clones and individuals is revealed, which suggests differential exposure to mutagens in the urine.
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Single-cell paired-end genome sequencing reveals structural variation per cell cycle
Thierry Voet,Parveen Kumar,Peter Van Loo,Susanna L. Cooke,John Marshall,Meng-Lay Lin,Masoud Zamani Esteki,Niels Van der Aa,Ligia Mateiu,David J. McBride,Graham R. Bignell,Stuart McLaren,Jon W. Teague,Adam Butler,Keiran Raine,Lucy Stebbings,Michael A. Quail,Thomas D'Hooghe,Yves Moreau,P. Andrew Futreal,Michael R. Stratton,Joris Vermeesch,Peter J. Campbell +22 more
TL;DR: Methods for paired-end sequence analysis of single-cell WGA products that enable detecting multiple classes of DNA mutation and fine-map a heritable inter-chromosomal rearrangement t(1;16)(p36;p12) by sequencing a single blastomere will expedite applications in basic genome research and provide a stepping stone to novel approaches for clinical genetic diagnosis.
Journal ArticleDOI
Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups
Niccolo Bolli,Niccolo Bolli,Giulia Biancon,Matahi Moarii,Silvia Gimondi,Yang Li,Chiara De Philippis,Francesco Maura,V. Sathiaseelan,Yu-Tzu Tai,Laura Mudie,Sarah O’Meara,Keiran Raine,Jon W. Teague,Adam Butler,Cristiana Carniti,Moritz Gerstung,Tina Bagratuni,Efstathios Kastritis,Meletios A. Dimopoulos,Paolo Corradini,Kenneth C. Anderson,Philippe Moreau,Stephane Minvielle,Peter J. Campbell,Elli Papaemmanuil,Hervé Avet-Loiseau,Nikhil C. Munshi +27 more
TL;DR: Clusters of patients stratified based on the overall number of mutations and number/type of CNAs are observed, suggesting that extended genotype of multiple myeloma at diagnosis may lead to improved disease classification and prognostication.