N
Nicholas Williams
Researcher at Wellcome Trust Sanger Institute
Publications - 13
Citations - 612
Nicholas Williams is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Haematopoiesis & Preeclampsia. The author has an hindex of 6, co-authored 13 publications receiving 260 citations. Previous affiliations of Nicholas Williams include University of Cambridge.
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Journal ArticleDOI
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia
Ralph McGinnis,Valgerdur Steinthorsdottir,Nicholas Williams,Gudmar Thorleifsson,Scott Shooter,Sigrun Hjartardottir,Suzannah Bumpstead,Lilja Stefansdottir,Lucy Hildyard,Jon K. Sigurdsson,John P. Kemp,John P. Kemp,Gabriela Silva,Liv Cecilie Vestrheim Thomsen,Liv Cecilie Vestrheim Thomsen,Tiina Jääskeläinen,Eero Kajantie,Eero Kajantie,Eero Kajantie,Sally Chappell,Noor Kalsheker,Ashley Moffett,Susan E. Hiby,Wai K. Lee,Sandosh Padmanabhan,Nigel Simpson,Vivien A. Dolby,Eleonora Staines-Urias,Eleonora Staines-Urias,Stephanie M. Engel,Anita Haugan,Lill Trogstad,Gulnara Svyatova,Nodira Zakhidova,Dilbar Najmutdinova,Anna F. Dominiczak,Håkon K. Gjessing,Håkon K. Gjessing,Juan P. Casas,Frank Dudbridge,James J. Walker,Fiona Broughton Pipkin,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Reynir Tómas Geirsson,Debbie A Lawlor,Ann-Charlotte Iversen,Per Magnus,Hannele Laivuori,Kari Stefansson,Kari Stefansson,Linda M. Morgan +51 more
TL;DR: The first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus, rs4769613, are reported, which may enhance understanding of the pathophysiology of preeclampsia and its subtypes.
Journal ArticleDOI
Extensive heterogeneity in somatic mutation and selection in the human bladder
Andrew R. J. Lawson,Federico Abascal,Tim H. H. Coorens,Yvette Hooks,Laura O’Neill,Calli Latimer,Keiran Raine,Mathijs A. Sanders,Mathijs A. Sanders,Anne Y. Warren,Krishnaa T. Mahbubani,Bethany Bareham,Tim Butler,Luke M. R. Harvey,Alex Cagan,Andrew Menzies,Luiza Moore,Luiza Moore,Alexandra Colquhoun,William Turner,Benjamin Thomas,Benjamin Thomas,Vincent Gnanapragasam,Nicholas Williams,Doris Rassl,Harald Vöhringer,Sonia Zumalave,Jyoti Nangalia,Jose M. C. Tubio,Jose M. C. Tubio,Moritz Gerstung,Kourosh Saeb-Parsy,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell,Thomas J. Mitchell,Thomas J. Mitchell,Inigo Martincorena +37 more
TL;DR: A rich landscape of mutational processes and selection in normal urothelium with large heterogeneity across clones and individuals is revealed, which suggests differential exposure to mutagens in the urine.
Journal ArticleDOI
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
Valgerdur Steinthorsdottir,Ralph McGinnis,Nicholas Williams,Lilja Stefansdottir,Gudmar Thorleifsson,Scott Shooter,João Fadista,João Fadista,Jon K. Sigurdsson,Kirsi M Auro,Galina Berezina,Maria Carolina Borges,Suzannah Bumpstead,Jonas Bybjerg-Grauholm,Irina Colgiu,Vivien A. Dolby,Frank Dudbridge,Stephanie M. Engel,Christopher S. Franklin,Michael L. Frigge,Yr Frisbaek,Reynir Tómas Geirsson,Frank Geller,Solveig Gretarsdottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Quaker E. Harmon,David M. Hougaard,Tatyana Hegay,Anna Helgadottir,Sigrun Hjartardottir,Tiina Jääskeläinen,Hrefna Johannsdottir,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorhildur Juliusdottir,Noor Kalsheker,Abdumadjit Kasimov,John P. Kemp,John P. Kemp,Katja Kivinen,Kari Klungsøyr,Kari Klungsøyr,Wai K. Lee,Mads Melbye,Mads Melbye,Mads Melbye,Zosia Miedzybrodska,Ashley Moffett,Dilbar Najmutdinova,Firuza Nishanova,Thorunn A. Olafsdottir,Thorunn A. Olafsdottir,Markus Perola,Markus Perola,Fiona Broughton Pipkin,Lucilla Poston,Gordon Prescott,Gordon Prescott,Saedis Saevarsdottir,Damilya Salimbayeva,Paula J. Scaife,Line Skotte,Eleonora Staines-Urias,Olafur A. Stefansson,Karina Meden Sørensen,Liv Cecilie Vestrheim Thomsen,Liv Cecilie Vestrheim Thomsen,Vinicius Tragante,Vinicius Tragante,Lill Trogstad,Nigel Simpson,Tamara Aripova,Juan P Casas,Juan P Casas,Anna F. Dominiczak,James J. Walker,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ann-Charlotte Iversen,Bjarke Feenstra,Debbie A Lawlor,Heather A. Boyd,Per Magnus,Hannele Laivuori,Hannele Laivuori,Nodira Zakhidova,Gulnara Svyatova,Kari Stefansson,Kari Stefansson,Linda Morgan +90 more
TL;DR: In genome-wide association meta-analysis of European and Central Asian mothers, sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12 are identified and it is shown that a polygenic risk score for hypertension associates with preeClampsia.
Journal ArticleDOI
Lineage tracing of human development through somatic mutations
Michael Spencer Chapman,Michael Spencer Chapman,Michael Spencer Chapman,Anna Maria Ranzoni,Anna Maria Ranzoni,Anna Maria Ranzoni,Brynelle Myers,Brynelle Myers,Brynelle Myers,Nicholas Williams,Tim H. H. Coorens,Emily Mitchell,Emily Mitchell,Emily Mitchell,Tim Butler,Kevin J. Dawson,Yvette Hooks,Luiza Moore,Luiza Moore,Jyoti Nangalia,Jyoti Nangalia,Jyoti Nangalia,Philip S. Robinson,Philip S. Robinson,Kenichi Yoshida,Elizabeth Hook,Peter J. Campbell,Peter J. Campbell,Ana Cvejic,Ana Cvejic,Ana Cvejic +30 more
TL;DR: In this paper, the ontogeny of the human haematopoietic system during fetal development has been characterized mainly through careful microscopic observations and deep targeted sequencing of tissues of known embryonic origin.
Journal ArticleDOI
Convergent somatic mutations in metabolism genes in chronic liver disease
Stanley W.K. Ng,Foad J. Rouhani,Simon F. Brunner,Natalia Brzozowska,Sarah J. Aitken,Ming Yang,Federico Abascal,Luiza Moore,Efterpi Nikitopoulou,Lia Chappell,Daniel Leongamornlert,Aleksandra Ivovic,Philip Robinson,Tim Butler,Mathijs A. Sanders,Mathijs A. Sanders,Nicholas Williams,Tim H. H. Coorens,Jon W. Teague,Keiran Raine,Adam Butler,Yvette Hooks,Beverley Wilson,Natalie Birtchnell,Huw W. Naylor,Susan E. Davies,Michael R. Stratton,Inigo Martincorena,Raheleh Rahbari,Christian Frezza,Matthew Hoare,Peter J. Campbell,Peter J. Campbell +32 more
TL;DR: In this paper, the authors analyzed 1,590 genomes across 34 liver samples, including healthy controls, alcohol-related liver disease and non-alcoholic fatty liver disease, and showed that these variants frequently exhibit convergent evolution, with variants acquired independently by up to nine distinct hepatocyte clones per patient.