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Kenji Matsumoto
Researcher at Saitama Medical University
Publications - 344
Citations - 12232
Kenji Matsumoto is an academic researcher from Saitama Medical University. The author has contributed to research in topics: Immunoglobulin E & Interleukin 33. The author has an hindex of 54, co-authored 319 publications receiving 10390 citations.
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Journal ArticleDOI
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.
Hiromi Fukushima-Uesaka,Yoshiro Saito,Hidemi Watanabe,Kisho Shiseki,Mayumi Saeki,Takahiro Nakamura,Kouichi Kurose,Kimie Sai,Kazuo Komamura,Kazuyuki Ueno,Shiro Kamakura,Masafumi Kitakaze,Sotaro Hanai,Toshiharu Nakajima,Kenji Matsumoto,Hirohisa Saito,Yu-ichi Goto,Hideo Kimura,Masaaki Katoh,Kenji Sugai,Narihiro Minami,Kuniaki Shirao,Tomohide Tamura,Noboru Yamamoto,Hironobu Minami,Atsushi Ohtsu,Teruhiko Yoshida,Nagahiro Saijo,Yutaka Kitamura,Naoyuki Kamatani,Shogo Ozawa,Jun-ichi Sawada +31 more
TL;DR: Using data from 186 subjects enabled a close linkage to be found between CYP3A4 and CYP2A5 SNPs, especially among the SNPs at c.1026+12 in CYP4 and c.1523 in CYp3A5, which suggested that CYP 3A4and CYP1A5 are within the same gene block.
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Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells.
Michishige Harada,Tomomitsu Hirota,Aya I. Jodo,Satoru Doi,Makoto Kameda,Kimie Fujita,Akihiko Miyatake,Tadao Enomoto,Emiko Noguchi,Shigemi Yoshihara,Motohiro Ebisawa,Hirohisa Saito,Kenji Matsumoto,Yusuke Nakamura,Steven F. Ziegler,Mayumi Tamari +15 more
TL;DR: Functional genetic polymorphism of the T SLP gene appears to contribute to Th2-polarized immunity through higher TSLP production by bronchial epithelial cells in response to viral respiratory infections.
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ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype
Shinsuke Hirabayashi,Kentaro Ohki,Kazuhiko Nakabayashi,Hitoshi Ichikawa,Yukihide Momozawa,Kohji Okamura,Akinori Yaguchi,Kazuki Terada,Yuya Saito,Ai Yoshimi,Hiroko Ogata-Kawata,Hiromi Sakamoto,Motohiro Kato,Junya Fujimura,Moeko Hino,Akitoshi Kinoshita,Harumi Kakuda,Hidemitsu Kurosawa,Keisuke Kato,Ryosuke Kajiwara,Koichi Moriwaki,Tsuyoshi Morimoto,Kozue Nakamura,Yasushi Noguchi,Tomoo Osumi,Kazuo Sakashita,Junko Takita,Yuki Yuza,Koich Matsuda,Teruhiko Yoshida,Kenji Matsumoto,Kenichiro Hata,Michiaki Kubo,Yoichi Matsubara,Takashi Fukushima,Katsuyoshi Koh,Atsushi Manabe,Akira Ohara,Nobutaka Kiyokawa +38 more
TL;DR: Observations indicate that ZNF384-related fusion genes consist of a distinct subgroup of B-cell precursor acute lymphoblastic leukemia with a characteristic immunophenotype, while the clinical features depend on the functional properties of individual fusion partners.
Journal ArticleDOI
Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
Toshiki Homma,Atsushi Kato,Noriko Hashimoto,Jonathan Batchelor,Mamoru Yoshikawa,Shosuke Imai,Hiroshi Wakiguchi,Hirohisa Saito,Kenji Matsumoto +8 more
TL;DR: Results provide evidence for a novel function of corticosteroids in airway inflammatory disorders, and indicate that the use of inhaled corticosterone in such disorders may have a beneficial role in host defense mechanisms.
Journal ArticleDOI
Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients.
Naomi Takahashi,Kenji Matsumoto,Hirohisa Saito,Toshihiro Nanki,Nobuyuki Miyasaka,Tetsuji Kobata,Miyuki Azuma,Sang Kyou Lee,Shuki Mizutani,Tomohiro Morio +9 more
TL;DR: It is suggested that extensive T cell dysfunction, decreased memory T cell compartment, and imbalance between effector and regulatory cells in ICOS-deficient patients may underlie their immunodeficiency and/or autoimmunity.