S
Saud H. AlDubayan
Researcher at Harvard University
Publications - 52
Citations - 2370
Saud H. AlDubayan is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Germline. The author has an hindex of 13, co-authored 39 publications receiving 1460 citations. Previous affiliations of Saud H. AlDubayan include University of Toronto & Boston Children's Hospital.
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Journal ArticleDOI
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer
Colin C. Pritchard,Joaquin Mateo,Michael Walsh,Navonil De Sarkar,Wassim Abida,Himisha Beltran,Andrea Garofalo,Roman Gulati,Suzanne Carreira,Rosalind A. Eeles,Olivier Elemento,Mark A. Rubin,Dan R. Robinson,Robert J. Lonigro,Maha Hussain,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Jake Vinson,Julie Filipenko,Levi A. Garraway,Mary-Ellen Taplin,Saud H. AlDubayan,G. Celine Han,Mallory Beightol,Colm Morrissey,Belinda Nghiem,Heather H. Cheng,Bruce Montgomery,Tom Walsh,Silvia Casadei,Silvia Casadei,Michael F. Berger,Liying Zhang,Ahmet Zehir,Joseph Vijai,Howard I. Scher,Charles L. Sawyers,Nikolaus Schultz,Philip W. Kantoff,David B. Solit,Mark E. Robson,Eliezer M. Van Allen,Kenneth Offit,Johann S. de Bono,Peter S. Nelson,Peter S. Nelson +45 more
TL;DR: The frequency of germline mutations in DNA-repair genes among men with metastatic prostate cancer significantly exceeded the prevalence of 4.6% among 499 men with localized prostate cancer and 2.7% in the Exome Aggregation Consortium, which includes 53,105 persons without a known cancer diagnosis.
Journal ArticleDOI
Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer
Daniel Nava Rodrigues,Daniel Nava Rodrigues,Pasquale Rescigno,Pasquale Rescigno,David Liu,David Liu,Wei Yuan,Suzanne Carreira,Maryou B. Lambros,George Seed,Joaquin Mateo,Joaquin Mateo,Ruth Riisnaes,Stephanie A. Mullane,Stephanie A. Mullane,Claire A. Margolis,Claire A. Margolis,Diana Miao,Diana Miao,Susana Miranda,David Dolling,Matthew Clarke,Claudia Bertan,Mateus Crespo,Gunther Boysen,Ana Ferreira,Adam Sharp,Ines Figueiredo,Daniel Keliher,Daniel Keliher,Saud H. AlDubayan,Saud H. AlDubayan,Kelly P. Burke,Semini Sumanasuriya,Mariane Sousa Fontes,Mariane Sousa Fontes,Diletta Bianchini,Diletta Bianchini,Zafeiris Zafeiriou,Zafeiris Zafeiriou,Larissa Sena Teixeira Mendes,Kent W. Mouw,Michael T. Schweizer,Michael T. Schweizer,Colin C. Pritchard,Stephen J. Salipante,Mary-Ellen Taplin,Himisha Beltran,Mark A. Rubin,Marcin Cieslik,Dan R. Robinson,Elizabeth Heath,Nikolaus Schultz,Joshua Armenia,Wassim Abida,Howard I. Scher,Christopher J. Lord,Alan D. D'Andrea,Charles L. Sawyers,Arul M. Chinnaiyan,Andrea Alimonti,Peter S. Nelson,Peter S. Nelson,Charles G. Drake,Eliezer M. Van Allen,Eliezer M. Van Allen,Johann S. de Bono,Johann S. de Bono +67 more
TL;DR: Higher MSINGS scores associated with dMMR, and these APCs were enriched for higher T cell infiltration and PD-L1 protein expression, could impact immune target selection, combination therapeutic strategy selection, and selection of predictive biomarkers for immunotherapy in APC.
Journal ArticleDOI
Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019
Veda N. Giri,Karen E. Knudsen,William Kevin Kelly,Heather H. Cheng,Kathleen A. Cooney,Michael S. Cookson,William L. Dahut,Scott Weissman,Howard R. Soule,Daniel P. Petrylak,Adam P. Dicker,Saud H. AlDubayan,Amanda E. Toland,Colin C. Pritchard,Curtis A. Pettaway,Mary B. Daly,James L. Mohler,J. Kellogg Parsons,Peter R. Carroll,Robert Pilarski,Amie Blanco,Ashley H. Woodson,Alanna Kulchak Rahm,Mary-Ellen Taplin,Thomas J. Polascik,Brian T. Helfand,Colette Hyatt,Alicia K. Morgans,Felix Y. Feng,Michael Russell Mullane,Jacqueline Powers,Raoul S. Concepcion,Daniel W. Lin,Richard C. Wender,James Ryan Mark,Anthony J. Costello,Arthur L. Burnett,Oliver Sartor,William B. Isaacs,Jianfeng Xu,Jeffrey N. Weitzel,Gerald L. Andriole,Himisha Beltran,Alberto Briganti,Lindsey Byrne,Anne Calvaresi,Thenappan Chandrasekar,David Y.T. Chen,Robert B. Den,Albert Dobi,E. David Crawford,James A. Eastham,Scott E. Eggener,Matthew L. Freedman,Marc B. Garnick,Patrick T. Gomella,Nathan Handley,Mark D. Hurwitz,Joseph K Izes,R. Jeffrey Karnes,Costas D. Lallas,Lucia R. Languino,Stacy Loeb,Ana Maria Lopez,Kevin R. Loughlin,Grace L. Lu-Yao,S. Bruce Malkowicz,Mark Mann,Patrick Mille,Martin Miner,Todd M. Morgan,Jose Moreno,Lorelei A. Mucci,Ronald E. Myers,Sarah M. Nielsen,Brock O'Neil,Wayne H. Pinover,Peter A. Pinto,Wendy Poage,Ganesh V. Raj,Timothy R. Rebbeck,Charles J. Ryan,Howard M. Sandler,Matthew J. Schiewer,E. Michael D. Scott,Brittany M. Szymaniak,William Tester,Edouard J. Trabulsi,Neha Vapiwala,Evan Y. Yu,Charnita Zeigler-Johnson,Leonard G. Gomella +91 more
TL;DR: This multidisciplinary, consensus-driven PCA genetic implementation framework provides novel guidance to clinicians and patients tailored to the precision era and includes optimal pretest informed consent, post-test discussion, cascade testing, and technology-based approaches.
Journal ArticleDOI
Genomic evolution and chemoresistance in germ-cell tumours
Amaro Taylor-Weiner,Amaro Taylor-Weiner,Travis I. Zack,Elizabeth O'Donnell,Jennifer L. Guerriero,Brandon Bernard,Anita Reddy,G. Celine Han,G. Celine Han,Saud H. AlDubayan,Saud H. AlDubayan,Ali Amin-Mansour,Steven E. Schumacher,Kevin Litchfield,Kevin Litchfield,Clare Turnbull,Clare Turnbull,Stacey Gabriel,Rameen Beroukhim,Rameen Beroukhim,Gad Getz,Gad Getz,Scott L. Carter,Michelle S. Hirsch,Anthony Letai,Christopher Sweeney,Eliezer M. Van Allen,Eliezer M. Van Allen +27 more
TL;DR: The results identify the convergence of cancer genomics, mitochondrial priming and GCT evolution, and may provide insights into chemosensitivity and resistance in other cancers.
Journal ArticleDOI
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations
Franklin W. Huang,Franklin W. Huang,Juan Miguel Mosquera,Andrea Garofalo,Coyin Oh,Maria B. Baco,Ali Amin-Mansour,Bokang Rabasha,Bokang Rabasha,Samira Bahl,Stephanie A. Mullane,Brian D. Robinson,Saud H. AlDubayan,Saud H. AlDubayan,Francesca Khani,Beerinder S. Karir,Eejung Kim,Eejung Kim,Jeremy Chimene-Weiss,Matan Hofree,Alessandro Romanel,Joseph R. Osborne,Joseph R. Osborne,Jong Wook Kim,Jong Wook Kim,Gissou Azabdaftari,Anna Woloszynska-Read,Karen S. Sfanos,Angelo M. De Marzo,Angelo M. De Marzo,Francesca Demichelis,Francesca Demichelis,Stacey Gabriel,Eliezer M. Van Allen,Eliezer M. Van Allen,Jill P. Mesirov,Jill P. Mesirov,Pablo Tamayo,Pablo Tamayo,Mark A. Rubin,Isaac J. Powell,Levi A. Garraway,Levi A. Garraway +42 more
TL;DR: Systematic genomic sequencing of prostate cancer in African-American men revealed new insights into prostate cancer, including the identification of ERF as a prostate cancer gene; somatic copy-number alteration differences; and uncommon PIK3CA and PTEN alterations.