K
Kie Itoh
Researcher at Johns Hopkins University School of Medicine
Publications - 34
Citations - 2522
Kie Itoh is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Mitochondrion & Mitochondrial fission. The author has an hindex of 17, co-authored 29 publications receiving 1980 citations. Previous affiliations of Kie Itoh include Johns Hopkins University & University of Tokyo.
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Journal ArticleDOI
Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid cells
Satohiro Okuda,Hiroki Tsutsui,Keiko Shiina,Stefanie Sprunck,Hidenori Takeuchi,Ryoko Yui,Ryushiro D. Kasahara,Yuki Hamamura,Akane Mizukami,Daichi Susaki,Nao Kawano,Takashi Sakakibara,Shoko Namiki,Kie Itoh,Kurataka Otsuka,Motomichi Matsuzaki,Hisayoshi Nozaki,Tsuneyoshi Kuroiwa,Akihiko Nakano,Masahiro M. Kanaoka,Thomas Dresselhaus,Narie Sasaki,Tetsuya Higashiyama +22 more
TL;DR: It is reported that secreted, cysteine-rich polypeptides (CRPs) in a subgroup of defensin-like proteins are attractants derived from the synergid cells of T. fournieri, and they showed activity in vitro to attract competent pollen tubes of their own species and were named as LUREs.
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Mitochondrial dynamics in neurodegeneration
TL;DR: The recent findings on mitochondrial dynamics in neurodegeneration are reviewed, with substantial evidence suggesting a key role in disease pathogenesis because neurons are among the most energy-consuming cell types and have a highly developed cell shape.
Journal ArticleDOI
The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
Evan A. Bordt,Pascaline Clerc,Brian A. Roelofs,Andrew J. Saladino,Andrew J. Saladino,Laszlo Tretter,Vera Adam-Vizi,Edward Cherok,Ahmed Khalil,Ahmed Khalil,Nagendra Yadava,Nagendra Yadava,Nagendra Yadava,Shealinna X. Ge,T. Chase Francis,Nolan W. Kennedy,Lora K. Picton,Tanya Kumar,Sruti Uppuluri,Alexandrea M. Miller,Kie Itoh,Mariusz Karbowski,Hiromi Sesaki,R. Blake Hill,Brian M. Polster +24 more
TL;DR: It is shown that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e.g., 50 μM) used to target mitochondrial fission.
Journal ArticleDOI
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease
Tatsuya Yamada,Daisuke Murata,Yoshihiro Adachi,Kie Itoh,Shoichiro Kameoka,Atsushi Igarashi,Takashi Kato,Yoichi Araki,Richard L. Huganir,Ted M. Dawson,Toru Yanagawa,Koji Okamoto,Miho Iijima,Hiromi Sesaki +13 more
TL;DR: The data provide a new concept that mitochondrial stasis leads the spatial dimension of mitochondria to a stationary equilibrium and a new mechanism for mitochondrial ubiquitination in mitophagy.
Journal ArticleDOI
Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease.
Liang Zhang,Sergey Trushin,Trace A. Christensen,Benjamin V. Bachmeier,Benjamin Gateno,Andreas S. Schroeder,Jia Yao,Kie Itoh,Hiromi Sesaki,Wayne W. Poon,Karen H. Gylys,Emily R. Patterson,Joseph E. Parisi,Roberta Diaz Brinton,Jeffrey L. Salisbury,Eugenia Trushina +15 more
TL;DR: A previously unknown mitochondrial fission arrest phenotype that results in elongated interconnected organelles, “mitochondria-on-a-string” (MOAS), is identified and argues for a major role of mitochondrial dynamics in regulating neuronal survival.