T
Toru Yanagawa
Researcher at University of Tsukuba
Publications - 148
Citations - 8276
Toru Yanagawa is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 34, co-authored 137 publications receiving 7344 citations.
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Journal ArticleDOI
Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
Masaaki Komatsu,Satoshi Waguri,Masato Koike,Yu-shin Sou,Yu-shin Sou,Takashi Ueno,Taichi Hara,Noboru Mizushima,Junichi Iwata,Junichi Iwata,Junji Ezaki,Shigeo Murata,Jun Hamazaki,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Toru Yanagawa,Junya Uwayama,Eiji Warabi,Hiroshi Yoshida,Tetsuro Ishii,Akira Kobayashi,Masayuki Yamamoto,Zhenyu Yue,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka +26 more
TL;DR: The findings highlight the unexpected role of homeostatic level of p62, which is regulated by autophagy, in controlling intracellular inclusion body formation, and indicate that the pathologic process associated with autophagic deficiency is cell-type specific.
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Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
Tetsuro Ishii,Ken Itoh,Satoru Takahashi,Hideyo Sato,Toru Yanagawa,Yasutake Katoh,Shiro Bannai,Masayuki Yamamoto +7 more
TL;DR: It is shown that Nrf2 controls the expression of a group of electrophile- and oxidative stress-inducible proteins and activities, which includes heme oxygenase-1, A170, peroxiredoxin MSP23, and cystine membrane transport (system xc −) activity.
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Listeria monocytogenes ActA-mediated escape from autophagic recognition
Yuko Yoshikawa,Michinaga Ogawa,Torsten Hain,Mitsutaka Yoshida,Makoto Fukumatsu,Minsoo Kim,Hitomi Mimuro,Ichiro Nakagawa,Toru Yanagawa,Tetsuro Ishii,Akira Kakizuka,Elizabeth Sztul,Trinad Chakraborty,Chihiro Sasakawa +13 more
TL;DR: It is shown that recruitment of the Arp2/3 complex and Ena/VASP, via the bacterial ActA protein, to the bacterial surface disguises the bacteria from autophagic recognition, an activity that is independent of the ability to mediate bacterial motility.
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Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
Takashi Shichita,Eiichi Hasegawa,Akihiro Kimura,Rimpei Morita,Ryota Sakaguchi,Ichiro Takada,Takashi Sekiya,Hiroaki Ooboshi,Takanari Kitazono,Toru Yanagawa,Tetsuro Ishii,Hideo Takahashi,Shuji Mori,Masahiro Nishibori,Kazumichi Kuroda,Shizuo Akira,Kensuke Miyake,Akihiko Yoshimura +17 more
TL;DR: Peroxiredoxin (Prx) family proteins released extracellularly from necrotic brain cells induce expression of inflammatory cytokines including interleukin-23 in macrophages through activation of Toll-like receptor 2 (TLR2) and TLR4, thereby promoting neural cell death, even though intracellular Prxs have been shown to be neuroprotective.
Journal ArticleDOI
Induction of osteoblast differentiation indices by statins in MC3T3‐E1 cells
Toyonobu Maeda,Ayako Matsunuma,Izuru Kurahashi,Toru Yanagawa,Hiroshi Yoshida,Noboru Horiuchi +5 more
TL;DR: Simvastatin at 10−7 M markedly increased mRNA expression for bone morphogenetic protein‐2 (BMP‐2), vascular endothelial growth factor (VEGF), alkaline phosphatase, type I collagen, bone sialoprotein, and osteocalcin in nontransformed osteoblastic cells, while suppressing gene expression for collagenase‐1, and collagenase'3.