Kiyoko Iwatsuki-Horimoto

TL;DR: It is observed that A(H7N9) virus infection of aged animals caused more severe symptoms than infection of young animals, and results suggest that attenuated or dysregulated immune responses in aged animals are responsible for the severe symptoms observed among elderly patients infected with A

TL;DR: Results provide direct evidence that immune responses to viral components other than HA confer protection against influenza A virus infection in a mouse model, suggesting the usefulness of live vaccines for viruses that have undergone antigenic drift with respect to HA, or for viruses with heterosubtypic HAs.

TL;DR: It is concluded that cats can be infected with human influenza viruses as well as avian influenza viruses in H5N1 virus-endemic areas and may act as an intermediate host for the emergence of new, potentially p and emic viruses.

TL;DR: The results show that even though aged individuals were likely exposed to more recent H2N2 viruses that are antigenically distinct from the earlier H2n2 viruses, they did not possess high neutralizing antibody titers to the more recent viruses, suggesting immunological imprinting of these individuals with the first H2 N2 viruses they encountered and that this immunologically imprinting lasts for over 50 years.

TL;DR: Although the vaccine response was low in the first season, it was improved in the second season and neutralizing antibody titers were determined before and after a single dose of pandemic (H1N1) 2009 influenza vaccine in HIV-1-positive Japanese adults.