K
Kiyoko Iwatsuki-Horimoto
Researcher at University of Tokyo
Publications - 111
Citations - 7279
Kiyoko Iwatsuki-Horimoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 32, co-authored 79 publications receiving 4640 citations.
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Journal ArticleDOI
Antibody titers against SARS-CoV-2 decline, but do not disappear for several months
Seiya Yamayoshi,Atsuhiro Yasuhara,Mutsumi Ito,Osamu Akasaka,Morio Nakamura,Ichiro Nakachi,Michiko Koga,Keiko Mitamura,Kazuma Yagi,Kenji Maeda,Hideaki Kato,Masanori Nojima,David J. Pattinson,Takayuki Ogura,Rie Baba,Kensuke Fujita,Hiroyuki Nagai,Shinya Yamamoto,Makoto Saito,Eisuke Adachi,Junichi Ochi,Shin ichiro Hattori,Tetsuya Suzuki,Yusuke Miyazato,Shiho Chiba,Moe Okuda,Jurika Murakami,Taiki Hamabata,Kiyoko Iwatsuki-Horimoto,Hideaki Nakajima,Hiroaki Mitsuya,Norio Omagari,Norio Sugaya,Hiroshi Yotsuyanagi,Yoshihiro Kawaoka,Yoshihiro Kawaoka +35 more
TL;DR: In this paper, a longitudinal study of antibody responses against SARS-CoV-2 in symptomatic patients was performed, and the results showed that the antibody response against the first SARS infection was typical of that observed in an acute viral infection.
Journal ArticleDOI
A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets
Masaki Imai,Tokiko Watanabe,Maki Kiso,Noriko Nakajima,Seiya Yamayoshi,Kiyoko Iwatsuki-Horimoto,Masato Hatta,Shinya Yamada,Mutsumi Ito,Yuko Sakai-Tagawa,Masayuki Shirakura,Emi Takashita,Seiichiro Fujisaki,Ryan McBride,Andrew J. Thompson,Kenta Takahashi,Tadashi Maemura,Hiromichi Mitake,Shiho Chiba,Gongxun Zhong,Shufang Fan,Kohei Oishi,Atsuhiro Yasuhara,Kosuke Takada,Tomomi Nakao,Satoshi Fukuyama,Makoto Yamashita,Tiago J. S. Lopes,Tiago J. S. Lopes,Gabriele Neumann,Takato Odagiri,Shinji Watanabe,Yuelong Shu,James C. Paulson,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +36 more
TL;DR: The results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored.
Journal ArticleDOI
Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets.
Masaki Imai,Makoto Yamashita,Yuko Sakai-Tagawa,Kiyoko Iwatsuki-Horimoto,Maki Kiso,Jurika Murakami,Atsuhiro Yasuhara,Kosuke Takada,Mutsumi Ito,Noriko Nakajima,Kenta Takahashi,Tiago J. S. Lopes,Tiago J. S. Lopes,Jayeeta Dutta,Zenab Khan,Divya Kriti,Harm van Bakel,Akifumi Tokita,Haruhisa Hagiwara,Naomi Izumida,Haruo Kuroki,Tamon Nishino,Noriyuki Wada,Michiko Koga,Eisuke Adachi,Daisuke Jubishi,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +28 more
TL;DR: It is reported that resistant viruses isolated from Japanese patients have normal replicative abilities and pathogenicity in animal models and thus might spread in humans.
Posted ContentDOI
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2
Yoshihiro Kawaoka,Ryuta Uraki,Maki Kiso,Shun Iida,Masaki Imai,Emi Takashita,Makoto Kuroda,Peter Halfmann,Samantha Loeber,Tadashi Maemura,Seiya Yamayoshi,Seiichiro Fujisaki,Zhongde Wang,Mutsumi Ito,Michiko Ujie,Kiyoko Iwatsuki-Horimoto,Yuri Furusawa,R. Wright,Zhenlu Chong,Seiya Ozono,Atsuhiro Yasuhara,Hiroshi Ueki,Yuko Sakai,Rongxiu Li,Yanan Liu,Deanna Larson,Michiko Koga,Takeya Tsutsumi,Eisuke Adachi,Makoto Saito,Shinya Yamamoto,Shohei Matsubara,Masao Hagihara,Keiko Mitamura,Tetsuro Sato,Masayuki Hojo,Shin-ichiro Hattori,Kenji Maeda,Moe Okuda,Jurika Murakami,C. Duong,Sucheta Godbole,Daniel C. Douek,Shinji Watanabe,Norio Ohmagari,Hiroshi Yotsuyanagi,Michael S. Diamond,Hideki Hasegawa,Hiroaki Mitsuya,Tadaki Suzuki +49 more
TL;DR: Findings suggest that the replication and pathogenicity of BA.2 is comparable to that ofBA.1 in rodents and that several therapeutic monoclonal antibodies and antiviral compounds are effective against Omicron/BA.2 variants.
Journal ArticleDOI
The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.
Hirotaka Imai,Kyoko Shinya,Ryo Takano,Maki Kiso,Yukiko Muramoto,Saori Sakabe,Shin Murakami,Mutsumi Ito,Shinya Yamada,Mai thi Quynh Le,Chairul A. Nidom,Yuko Sakai-Tagawa,Kei Takahashi,Yasuyuki Omori,Takeshi Noda,Masayuki Shimojima,Satoshi Kakugawa,Hideo Goto,Kiyoko Iwatsuki-Horimoto,Taisuke Horimoto,Yoshihiro Kawaoka +20 more
TL;DR: It is found that the residue at position 134 of HA alters the receptor-binding property of the virus, as measured by viral elution from erythrocytes, and both of the residues at positions 200 and 205 of NS1 contributed to enhanced type I interferon (IFN) antagonistic activity.