S
Saffron A.G. Willis-Owen
Researcher at National Institutes of Health
Publications - 57
Citations - 6420
Saffron A.G. Willis-Owen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Gene. The author has an hindex of 29, co-authored 55 publications receiving 5824 citations. Previous affiliations of Saffron A.G. Willis-Owen include University of Oxford & Wellcome Trust Centre for Human Genetics.
Papers
More filters
Journal ArticleDOI
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
Miriam F. Moffatt,Michael Kabesch,Liming Liang,Anna L. Dixon,David P. Strachan,Simon Heath,Martin Depner,Andrea von Berg,Albrecht Bufe,Ernst Rietschel,Andrea Heinzmann,Burkard Simma,Thomas Frischer,Saffron A.G. Willis-Owen,Kenny C. C. Wong,Thomas Illig,Christian Vogelberg,Stephan K. Weiland,Erika von Mutius,Gonçalo R. Abecasis,Martin Farrall,Ivo Gut,G. Mark Lathrop,William O.C.M. Cookson +23 more
TL;DR: The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.
Journal ArticleDOI
The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis
PL Molyneaux,Michael J. Cox,Saffron A.G. Willis-Owen,Patrick Mallia,Kirsty E. Russell,Anne-Marie Russell,Elissa Murphy,Sebastian L. Johnston,David A. Schwartz,Athol U. Wells,William O.C.M. Cookson,Toby M. Maher,Miriam F. Moffatt +12 more
TL;DR: IPF is characterized by an increased bacterial burden in BAL that predicts decline in lung function and death, and trials of antimicrobial therapy are needed to determine if microbial burden is pathogenic in the disease.
Journal ArticleDOI
Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data.
TL;DR: The DRD4 gene may be associated with measures of novelty seeking and impulsivity but not extraversion, and the association of the C-521T variant with these measures, if genuine, may account for up to 3% of phenotypic variance.
Journal ArticleDOI
Variants of DENND1B Associated with Asthma in Children
Patrick M. A. Sleiman,James H. Flory,Marcin Imielinski,Jonathan P. Bradfield,Kiran Annaiah,Saffron A.G. Willis-Owen,Kai Wang,Nicholas Rafaels,Sven Michel,Klaus Bønnelykke,Haitao Zhang,Cecilia E. Kim,Edward C. Frackelton,Joseph T. Glessner,Cuiping Hou,F. George Otieno,Erin Santa,Kelly A. Thomas,Ryan M. Smith,Wendy Glaberson,Maria Garris,Rosetta M. Chiavacci,Terri H. Beaty,Ingo Ruczinski,Jordan M. Orange,Julian L. Allen,Jonathan M. Spergel,Robert W. Grundmeier,Rasika A. Mathias,Jason D. Christie,Erika von Mutius,William O.C.M. Cookson,Michael Kabesch,Miriam F. Moffatt,Michael M. Grunstein,Kathleen C. Barnes,Marcella Devoto,Mark R. Magnusson,Hongzhe Li,Struan F.A. Grant,Hans Bisgaard,Hakon Hakonarson +41 more
TL;DR: A locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma is identified and predicted to interact with the tumor necrosis factor α receptor.
Journal ArticleDOI
Genome-wide Association Analysis Identifies PDE4D as an Asthma-Susceptibility Gene
Blanca E. Himes,Gary M. Hunninghake,James W. Baurley,Nicholas Rafaels,Patrick M. A. Sleiman,David P. Strachan,Jemma B. Wilk,Saffron A.G. Willis-Owen,Barbara J. Klanderman,Jessica Lasky-Su,Ross Lazarus,Amy Murphy,Manuel E. Soto-Quiros,Lydiana Avila,Terri H. Beaty,Rasika A. Mathias,Ingo Ruczinski,Kathleen C. Barnes,Juan C. Celedón,William O.C.M. Cookson,W. James Gauderman,Frank D. Gilliland,Hakon Hakonarson,Christoph Lange,Miriam F. Moffatt,George T. O'Connor,Benjamin A. Raby,Edwin K. Silverman,Scott T. Weiss +28 more
TL;DR: A genome-wide association study of asthma with 359 cases from the Childhood Asthma Management Program and 846 genetically matched controls found the strongest region of association seen was on chromosome 5q12 in PDE4D, a regulator of airway smooth-muscle contractility.