R
Ramu Chenna
Researcher at Dresden University of Technology
Publications - 7
Citations - 5594
Ramu Chenna is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Massive parallel sequencing & X-linked intellectual disability. The author has an hindex of 5, co-authored 7 publications receiving 5391 citations. Previous affiliations of Ramu Chenna include Max Planck Society.
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Journal ArticleDOI
Multiple sequence alignment with the Clustal series of programs
Ramu Chenna,Hideaki Sugawara,Tadashi Koike,Rodrigo Lopez,Toby J. Gibson,Desmond G. Higgins,Julie D. Thompson +6 more
TL;DR: The Clustal series of programs, widely used in molecular biology for the multiple alignment of both nucleic acid and protein sequences and for preparing phylogenetic trees, are extended.
Journal ArticleDOI
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes
Hao Hu,Stefan A. Haas,Jamel Chelly,Jamel Chelly,H Van Esch,Martine Raynaud,A.P.M. de Brouwer,Stefanie Weinert,Guy Froyen,Suzanna G.M. Frints,Frédéric Laumonnier,Tomasz Zemojtel,Michael I. Love,Hugues Richard,Anne-Katrin Emde,M Bienek,C Jensen,Melanie Hambrock,Utz Fischer,Claudia Langnick,Mirjam Feldkamp,Willemijn M. Wissink-Lindhout,Nicolas Lebrun,Nicolas Lebrun,L. Castelnau,L. Castelnau,Julien Rucci,Julien Rucci,R. Montjean,R. Montjean,Olivier Dorseuil,Olivier Dorseuil,Pierre Billuart,Pierre Billuart,T. Stuhlmann,Marie Shaw,Mark A. Corbett,Alison Gardner,Saffron A.G. Willis-Owen,Saffron A.G. Willis-Owen,C Tan,Kathryn Friend,Stefanie Belet,K. E. P. van Roozendaal,M Jimenez-Pocquet,Marie-Pierre Moizard,Nathalie Ronce,Ruping Sun,Sean O'Keeffe,Ramu Chenna,A. van Bömmel,Jonathan Göke,Anna Hackett,Michael Field,Louise Christie,Jackie Boyle,Eric Haan,Eric Haan,John Nelson,Gillian Turner,Gareth Baynam,Gabriele Gillessen-Kaesbach,Ulrich Müller,Daniela Steinberger,Bartłomiej Budny,Magdalena Badura-Stronka,Anna Latos-Bielenska,Lilian Bomme Ousager,Peter Wieacker,G. Rodríguez Criado,Marie-Louise Bondeson,Göran Annerén,Andreas Dufke,Monika Cohen,L. Van Maldergem,Catherine Vincent-Delorme,Bernard Echenne,B. Simon-Bouy,Tjitske Kleefstra,Marjolein H. Willemsen,J. P. Fryns,Koenraad Devriendt,Reinhard Ullmann,Martin Vingron,Klaus Wrogemann,Klaus Wrogemann,Thomas F. Wienker,Andreas Tzschach,H Van Bokhoven,Jozef Gecz,Thomas J. Jentsch,Wei Chen,Hans-Hilger Ropers,Vera M. Kalscheuer +93 more
TL;DR: It is suggested that systematic sequencing of all X-chromosomal genes in a cohort of patients with genetic evidence for X- Chromosome locus involvement may resolve up to 58% of Fragile X-negative cases.
Journal ArticleDOI
Hes3 Is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin Release *
Jimmy Masjkur,Carina Arps-Forker,Steven W. Poser,Polyxeni Nikolakopoulou,Louiza Toutouna,Ramu Chenna,Triantafyllos Chavakis,Antonis Chatzigeorgiou,Lan-Sun Chen,Anna Dubrovska,Pratik Choudhary,Ingo Uphues,Michael Mark,Stefan R. Bornstein,Andreas Androutsellis-Theotokis +14 more
TL;DR: Roles of Hes3 in pancreatic islet function are suggested and it is suggested that the transcription factor is a novel regulator of cellular functions of importance in diabetes.
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A high-throughput siRNA screen identifies genes that regulate mannose 6-phosphate receptor trafficking.
Mihaela Anitei,Ramu Chenna,Cornelia Czupalla,Milan Ešner,Sara Christ,Steffi Lenhard,Kerstin Korn,Felix Meyenhofer,Marc Bickle,Marino Zerial,Bernard Hoflack +10 more
TL;DR: This analysis maps the MPR trafficking pathways based on enzymes regulating phosphatidylinositol phosphate metabolism and reveals how cell signaling controls the biogenesis of post-Golgi tubular carriers destined to enter the endosomal system through a SRC-dependent pathway regulating ARF1 and RAC1 signaling and myosin II activity.
Journal ArticleDOI
Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting.
Marta Nedelkova,Marcello Maresca,Jun Fu,Mariya Rostovskaya,Ramu Chenna,Christian Thiede,Konstantinos Anastassiadis,Mihail Sarov,A. Francis Stewart +8 more
TL;DR: A strategy for targeted isolation of large regions from human genomes that is also applicable to any genome of interest and relies on recombineering to fish out target fosmid clones from pools and thereby circumvents the laborious need to plate and screen thousands of individual clones.