K
Konrad Zych
Researcher at European Bioinformatics Institute
Publications - 12
Citations - 998
Konrad Zych is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 7, co-authored 10 publications receiving 476 citations. Previous affiliations of Konrad Zych include Jagiellonian University & University of Groningen.
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Journal ArticleDOI
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Jakob Wirbel,Paul Theodor Pyl,Paul Theodor Pyl,Ece Kartal,Konrad Zych,Alireza Kashani,Alessio Milanese,Jonas S. Fleck,Anita Y. Voigt,Albert Pallejà,Ruby Ponnudurai,Shinichi Sunagawa,Luis Pedro Coelho,Petra Schrotz-King,Emily Vogtmann,Nina Habermann,Emma Niméus,Andrew Maltez Thomas,Andrew Maltez Thomas,Paolo Manghi,Sara Gandini,Davide Serrano,Sayaka Mizutani,Sayaka Mizutani,Hirotsugu Shiroma,Satoshi Shiba,Tatsuhiro Shibata,Shinichi Yachida,Takuji Yamada,Takuji Yamada,Levi Waldron,Alessio Naccarati,Nicola Segata,Rashmi Sinha,Cornelia M. Ulrich,Hermann Brenner,Manimozhiyan Arumugam,Manimozhiyan Arumugam,Peer Bork,Georg Zeller +39 more
TL;DR: A meta-analysis of eight geographically and technically diverse fecal shotgun metagenomic studies of colorectal cancer identified a core set of 29 species significantly enriched in CRC metagenomes, establishing globally generalizable, predictive taxonomic and functional microbiome CRC signatures as a basis for future diagnostics.
Journal ArticleDOI
Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox
Jakob Wirbel,Konrad Zych,Morgan Essex,Morgan Essex,Nicolai Karcher,Nicolai Karcher,Ece Kartal,Guillem Salazar,Peer Bork,Shinichi Sunagawa,Georg Zeller +10 more
TL;DR: In this paper, the authors developed SIAMCAT, a toolbox for ML-based comparative metagenomics, which demonstrated its capabilities in a meta-analysis of fecal metagenomic studies (10,803 samples).
Journal ArticleDOI
Mechanism of Selective Halogenation by SyrB2: A Computational Study
TL;DR: Computed relative energies and Mössbauer isomer shifts as well as quadrupole splittings indicate that the two oxoferryl species observed experimentally are two stereoisomers resulting from an exchange of the coordination sites occupied by the oxo and chloro ligands.
Journal ArticleDOI
A faecal microbiota signature with high specificity for pancreatic cancer
Ece Kartal,Thomas Schmidt,Esther Molina-Montes,Sandra Rodriguez-Perales,Jakob Wirbel,Oleksandr M. Maistrenko,Wasiu Akanni,Bilal Alashkar Alhamwe,Renato J. Alves,Alfredo Carrato,Hans-Peter Erasmus,Lidia Estudillo,Fabian Finkelmeier,Anthony Fullam,Anna Głazek,Paulina Gomez-Rubio,Rajna Hercog,Ferris Jung,Stefanie Kandels,Stephan Kersting,Melanie Langheinrich,Mirari Marquez,Xavier Molero,Askarbek N Orakov,Thea Van Rossum,Raúl Torres-Ruiz,Anja Telzerow,Konrad Zych,Vladimir Benes,Georg Zeller,Jonel Trebicka,Francisco X. Real,Núria Malats,Peer Bork +33 more
TL;DR: Faecal metagenomic classifiers performed much better than saliva-based classifiers and identified patients with PDAC with an accuracy of up to 0.84 area under the receiver operating characteristic curve (AUROC) based on a set of 27 microbial species, with consistent accuracy across early and late disease stages.
Posted ContentDOI
Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine-learning toolbox
Jakob Wirbel,Konrad Zych,Morgan Essex,Morgan Essex,Nicolai Karcher,Nicolai Karcher,Ece Kartal,Guillem Salazar,Peer Bork,Shinichi Sunagawa,Georg Zeller +10 more
TL;DR: SIAMCAT, a versatile R toolbox for ML-based comparative metagenomics, is developed and demonstrated its capabilities in a meta-analysis of fecal metagenomic studies, revealing some biomarkers to be disease-specific, others shared across multiple conditions.