K
Kuixing Zhang
Researcher at University of California, San Diego
Publications - 49
Citations - 1289
Kuixing Zhang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Chromogranin A & Population. The author has an hindex of 20, co-authored 49 publications receiving 1211 citations. Previous affiliations of Kuixing Zhang include Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Whole-Genome Analysis of Sporadic Amyotrophic Lateral Sclerosis
Travis Dunckley,Matthew J. Huentelman,David Craig,John V. Pearson,Szabolcs Szelinger,Keta Joshipura,Rebecca F. Halperin,Chelsea Stamper,Kendall Jensen,David Letizia,Sharon E. Hesterlee,Alan Pestronk,Todd Levine,Tulio E. Bertorini,Michael C. Graves,Tahseen Mozaffar,Carlayne E. Jackson,Peter Bosch,April McVey,Arthur Dick,Richard J. Barohn,Catherine Lomen-Hoerth,Jeffrey Rosenfeld,Daniel T. O'Connor,Kuixing Zhang,Richard Crook,Henrik Ryberg,Mike Hutton,Jonathan S. Katz,Ericka Simpson,Hiroshi Mitsumoto,Robert Bowser,Robert G. Miller,Stanley H. Appel,Dietrich A. Stephan +34 more
TL;DR: Variants of FLJ10986 may confer susceptibility to sporadic ALS and 50 other candidate loci warrant further investigation for their potential role in conferring susceptibility to the disease.
Journal ArticleDOI
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.
Fangwen Rao,Lian Zhang,Jennifer Wessel,Kuixing Zhang,Gen Wen,Brian P. Kennedy,Brinda K. Rana,Madhusudan Das,Juan L. Rodriguez-Flores,Douglas W. Smith,Peter E. Cadman,Rany M. Salem,Sushil K. Mahata,Nicholas J. Schork,Laurent Taupenot,Michael G. Ziegler,Daniel T. O'Connor +16 more
TL;DR: Catecholamine secretory traits are heritable, displaying joint genetic determination with autonomic activity and finally with blood pressure in the population, and C-824T showed pleiotropy, increasing both norepinephrine excretion and blood pressure during stress.
Journal ArticleDOI
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
Lian Zhang,Fangwen Rao,Kuixing Zhang,Srikrishna Khandrika,Madhusudan Das,Sucheta M. Vaingankar,Xuping Bao,Brinda K. Rana,Douglas W. Smith,Jennifer Wessel,Rany M. Salem,Juan L. Rodriguez-Flores,Sushil K. Mahata,Sushil K. Mahata,Nicholas J. Schork,Michael G. Ziegler,Daniel T. O'Connor,Daniel T. O'Connor +17 more
TL;DR: The results document novel pathophysiological links between a key biosynthetic locus and NO metabolism and suggest new strategies for approaching the mechanism, diagnosis, and treatment of risk predictors for cardiovascular diseases such as hypertension.
Journal ArticleDOI
Heritability and Genome-Wide Linkage in US and Australian Twins Identify Novel Genomic Regions Controlling Chromogranin A Implications for Secretion and Blood Pressure
Daniel T. O'Connor,Gu Zhu,Fangwen Rao,Laurent Taupenot,Maple M. Fung,Madhusudan Das,Sushil K. Mahata,Manjula Mahata,Lei Wang,Kuixing Zhang,Tiffany A. Greenwood,Pei-an Betty Shih,Myles Cockburn,Michael G. Ziegler,Mats Stridsberg,Nicholas G. Martin,John Whitfield +16 more
TL;DR: Variation influenced CHGA secretion and processing to catestatin, confirming the mechanism of a novel trans-QTL for sympathochromaffin activity and blood pressure.
Journal ArticleDOI
Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.
Yuqing Chen,Gen Wen,Fangwen Rao,Kuixing Zhang,Lei Wang,Juan L. Rodriguez-Flores,Amber P. Sanchez,Manjula Mahata,Laurent Taupenot,Ping Sun,Sushil K. Mahata,Bamidele O. Tayo,Nicholas J. Schork,Michael G. Ziegler,Bruce A. Hamilton,Daniel T. O'Connor +15 more
TL;DR: Investigation of DBH polymorphisms associated with enzymatic activity as well as autonomic and blood pressure (BP)/disease phenotypes in vivo suggests common genetic variation in the DBH promoter region seems to initiate a cascade of biochemical and physiological changes eventuating in alterations of basal BP.