L
Laura E. Ruff
Researcher at Vaccine Research Center
Publications - 8
Citations - 3066
Laura E. Ruff is an academic researcher from Vaccine Research Center. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 7, co-authored 8 publications receiving 2951 citations. Previous affiliations of Laura E. Ruff include National Institutes of Health.
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Journal ArticleDOI
CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract
Jason M. Brenchley,Timothy W. Schacker,Laura E. Ruff,David Price,Jodie H. Taylor,Gregory J. Beilman,Phuong L. Nguyen,Alexander Khoruts,Matthew Larson,Ashley T. Haase,Daniel C. Douek +10 more
TL;DR: The nature and extent of CD4+ T cell depletion in lymphoid tissue is defined and mechanisms of profound depletion of specific T cell subsets related to elimination of CCR5+ CD4- T cell targets and disruption of T cell homeostasis that accompanies chronic immune activation are pointed to.
Journal ArticleDOI
Avidity for antigen shapes clonal dominance in CD8 + T cell populations specific for persistent DNA viruses
David Price,Jason M. Brenchley,Laura E. Ruff,Michael R. Betts,Brenna J. Hill,Mario Roederer,Richard A. Koup,S.A. Migueles,Emma Gostick,Linda Wooldridge,Andrew K. Sewell,Mark Connors,Daniel C. Douek +12 more
TL;DR: Evidence is provided that interclonal competition for antigen operates in human T cell populations, while preferential CD8 coreceptor compensation mitigates this process to maintain clonotypic diversity.
Journal ArticleDOI
Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
Joseph P. Casazza,Michael R. Betts,David Price,Melissa L. Precopio,Laura E. Ruff,Jason M. Brenchley,Brenna J. Hill,Mario Roederer,Daniel C. Douek,Richard A. Koup +9 more
TL;DR: Mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes, as well as a terminally differentiated phenotype that was not characterized by a distinct clonotypic composition.
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T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection
David Price,Sadie M. West,Michael R. Betts,Laura E. Ruff,Jason M. Brenchley,David R. Ambrozak,Yvette Edghill-Smith,Marcelo J. Kuroda,Derek Bogdan,Kevin J. Kunstman,Norman L. Letvin,Genoveffa Franchini,Steven M. Wolinsky,Richard A. Koup,Daniel C. Douek +14 more
TL;DR: Analysis of 3416 SIV-specific TCR sequences revealed that polyclonal T cell populations characterized by highly conserved TCRB CDR3 motifs were rendered ineffectual by single residue mutations in the cognate viral epitope, directing the pattern of adaptive viral evolution.
Journal ArticleDOI
High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
Christoph Berger,Nicole Frahm,David Price,David Price,Beatriz Mothe,Musie Ghebremichael,Kari L. Hartman,Leah M. Henry,Jason M. Brenchley,Laura E. Ruff,Vanessa Venturi,Florencia Pereyra,John Sidney,Alessandro Sette,Daniel C. Douek,Bruce D. Walker,Bruce D. Walker,Daniel Kaufmann,Christian Brander,Christian Brander +19 more
TL;DR: Data link the presence of high-avidity Gag-specific and HLA-B-restricted CTL responses with viral suppression in vivo and provide new insights into the immune parameters that mediate spontaneous control of HIV infection.